肾交感神经射频消融术治疗顽固性高血压的研究进展

原发性高血压是以体循环动脉压增高为主要表现的临床综合征,长期高血压可影响重要脏器尤其是心、肺、肾的功能,最终导致脏器功能衰竭。顽固性高血压也称为难治性高血压,定义为在改善生活方式的基础上,应用足够剂量且合理的3种或以上降压药物(包括利尿剂)之后血压仍未达标。此类患者易发生多种危重并发症如心脑血管意外(如脑卒中、心力衰竭、心肌梗死等)、肾功能衰竭,甚至猝死。因此,应积极调整不当生活方式、采用合理药物治疗以最大程度降低血压,若血压仍控制不佳的高危患者可考虑肾交感神经射频消融术。

Study process of treating resistant hypertension by renal sympathetic denervation

Primary hypertension is a syndrome which characterizes as elevated arterial blood pressure of systemic circulation.Long term of high blood pressure may cause drawbacks on important organs such as heart, lung and kidney which may due to function loss at last.Resistant hypertension is defined as blood pressure above the target range set by current guidelines despite the control of lifestyle and three or more antihypertensive drugs of different classes,including a diuretic,at their maximum or highest tolerated doses. Those patients are at a high risk of the occurrence cerebro-vascular events which may threaten their lives. As a result,it is quite critical to control blood pressure in these people,with improving lifestyle and better drug combination,or renal sympathetic denervation.