Medium- and high-dose omeprazole plus amoxicillin for eradication ofHelicobacter pylori in duodenal ulcer disease |
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Authors: | Dr. Joachim Labenz MD Georg H. Rühl MD Jörg Bertrams Gereon Börsch MD |
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Affiliation: | (1) From the Department of Internal Medicine, Elisabeth Hospital, Academic Teaching Hospital of the University of Essen, Essen, Germany;(2) Department of Laboratory Medicine, Elisabeth Hospital, Academic Teaching Hospital of the University of Essen, Essen, Germany;(3) Institute of Pathology, Ruhruniversity Bochum, Germany |
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Abstract: | The purpose of the present study was to investigate theHelicobacter pylori eradication potency of combined amoxicillin-omeprazole treatment in patients with duodenal ulcer disease and to compare the efficacy of two omeprazole and amoxicillin doses concerningH. pylori eradication, ulcer healing, pain relief, and safety. Ninety patients with activeH. pylori-positive (culture and/or histology) duodenal ulcer disease were randomly treated with either omeprazole 20 mg twice a day plus amoxicillin 1 g twice a day (group I,N=30), omeprazole 40 mg twice a day plus amoxicillin 1 g twice a day (group II,N=30), or omeprazole 40 mg twice a day plus amoxicillin 1 g three times a day (group III,N=30) over two weeks, followed by ranitidine at bedtime for another four weeks. The overall proportion ofH. pylori eradication was 83% and of ulcer healing 92% without statistically significant differences between the study groups. Complete pain relief occurred after a median of one day in all groups. Six patients complained of side effects during the therapy phase, which led to therapy discontinuation in one female patient. In conclusion, omeprazole plus amoxicillin is a highly effective and well-tolerated therapy regimen to eradicateH. pylori in duodenal ulcer disease. In addition, the results suggest that there is no clear dose-response relation between the dosages of omeprazole and amoxicillin used in this study on the one hand and theH. pylori eradication rates on the other. |
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Keywords: | amoxicillin duodenal ulcer Helicobacter pylori omeprazole |
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