奥曲肽对胰腺炎相关性腹水所致肠损伤的疗效

目的 观察胰腺炎相关性腹水(PAAF)对大鼠肠的损伤作用及奥曲肽对该损伤的疗效.方法 将48只SD大鼠随机分为空白对照组(A组)、模型对照组(B组)和奥曲肽治疗组(C组),B组、C组腹腔内注射PAAF,C组用奥曲肽治疗,测定血清内毒素(LPS)和肿瘤坏死因子(TNF)-α;测定小肠组织的ATP酶和TNF-α;观察肠黏膜的病理变化.结果 B组与A组比较,除ATP酶活性显著下降(P<0.05)外,上述指标均显著增高(P<0.05;)C组与B组比较,除ATP酶活性较模型对照组显著增高(P<0.05)外,上述指标均较之明显下降(P<0.05).结论 奥曲肽能够减轻PAAF诱导的大鼠肠损伤.

Curative effect of octreotide in the treatment of the intestine harm induced by pancreatitis associated ascetic fluid

Objective To investigate the curative effect of octyeotide in the treatment of the intes tine harm induced by pancreatitis associated ascetic fluid (PAAF) in rats. Methods Forty-eight healthy Sprague-Dawwley (SD) rats were randomly divided into three groups:blank group (A) ,model group (B) and octreotide treatment group (C). PAAF was intraperitoneally injected in groups B and C,and octreotide was given in group C. The levels of serum lipopolysaccharides (LPS) and tumor necrosis factor a (TNF-α) were determined, and those of ATP enzyme and TNF-α were measured in intestinal tissues. The pathological changes of intestinal mucosa were observed. Results Except that the activity of ATP was decreased (P < 0.05) ,the indexes above were all increased (P<0.05) in group A as compared with group B (P<0.05). Except that the activity of ATP enzyme was greatly increased (P <0.05) ,all the other indexes were obviously de creased in group C as compared with group B (P <0.05). Conclusion Octreotide can alleviate the the intes tine harm induced by PAAF.