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Nutrition of cruciate ligament reconstruction by diffusion. Collagen synthesis studied in rabbits
Authors:D Amiel  W H Akeson  S Renzoni  F Harwood  M Abel
Abstract:The reconstructed anterior cruciate ligament was studied in the rabbit using the medial third of the patellar tendon. Tritiated proline, 100 microCi/kg body weight, was injected intra-articularly to insure detection of the metabolic conversion product 3H-hydroxyproline in the avascular graft. During the immediate postoperative period, nutrients were found to derive from the synovial fluid through a process of diffusion, demonstrating that synovial nutrition occurs prior to revascularization of the graft.
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