硝普钠及硝酸甘油在经桡动脉行冠状动脉介入应用的对比研究

目的探讨血管解痉药硝普钠和硝酸甘油对桡动脉痉挛的临床效果。方法选取2006年8月-2008年6月Allen实验阳性并经桡动脉途径行冠状动脉造影及经皮冠状动脉介入治疗的患者160例，随机分为硝普钠组（A组，80例）和硝酸甘油组（B组，80例）。桡动脉穿刺成功后，A组常规鞘内注入硝普钠0．1mg（生理盐水10ml稀释），至腋动脉时再次注入硝普钠0．1mg（生理盐水10ml稀释）：B组常规鞘内注入硝酸甘油0．2mg，然后行CAG和PCI术，观察两组桡动脉痉挛发生率。结果A组桡动脉痉挛发生率为1．25％（1／80），B组桡动脉痉挛发生率为12．5％（10／80），两组间桡动脉痉挛发生率比较有显著性差异（P〈0．05）。结论硝普钠对缓解桡动脉痉挛作用效果好。

Comparison study of arterial anticonvulsive drug in percutaneous radial artery approach for coronary intervention

Objective To evaluate the effect of nitroglycerin and Sodium Nitroprus-side on relaxing spasm of radial artery. In percutaneous radial artery approach for coronary intervention(PCI).Methoda 160 patientson Aug, 2006 to Jun 2008 were collected.All of the 160 patients received percutaneous radial artery approach for coronary interven-tion and were divided into group A and group B by arterial injection with Sodium Nitroprus-side or nitroglycerin.The age and gender of patients were no significant difference in two groups. After puncture of the radial artery successfully, the patients in group A were arterial injection Sodium Nitroprusside and group B arterial injection nitroglycerin.All of patients received PCI. Observe the incidence of radial arleriospasm. Results The two groups, the incidence of radial artefiospasm was 1.25%(1/80)VS12.5%(10/80). This differ-ence was significant statistical significance(P<0.05).Conclusion The Sodium Nitroprus-side is better than nitroglycerin in relaxing spasm of radial artery.