金钱草对铅暴露低龄大鼠体内铅负荷影响的实验研究

目的观察金钱草对体内铅负荷增高的低龄大鼠的排铅效果,为开发低毒有效的排铅药物提供依据。方法对1月龄SD大鼠饮水给予1%醋酸铅,造成大鼠体内铅含量升高模型后,用金钱草煎剂经口服灌胃促排铅,测定血、肝组织中铅含量及肾功生化指标的变化,并对金钱草是否在体外与铅离子发生络合进行初步分析。结果金钱草促排组血铅含量显著低于阳性模型组和自排组(P<0.05)。各组大鼠肾功能生化指标间差异无显著意义。金钱草在体外可与铅离子发生络合作用。结论金钱草对大鼠体内的铅有一定促排作用,金钱草煎剂在体外和铅离子可以进行络合,其作用机制有待进一步的研究。

Effect of Christina loosestrife herb on body lead-load in lead-exposed young rats

Objective To observe the leadeliminating ability of Christina loosestrife herb in young rats subchronically exposed to lead.MethodSD rats were randomly divided by weight into three groups:control group,lead exposed group and Christina loosestrife herb treated leadexposing group;lead was given by giving lead-contained drinking water(1% lead acetate)for three weeks,then the rats of treated group were given Christina loosestrife herb by stomach perfusion for four weeks.Then the lead levels in blood and liver,and the renal function were determined at the same time.Additionally,other experiment was done to find out that whether Christina loosestrife herb can directly combine with lead ion in vitro.ResultThe study showed that Christina loosestrife herb can significantly reduce the lead levels in blood and liver of lead exposed rats,without obvious negative effect on renal function,while Christina loosestrife herb showed the ability of combining with lead ion in vitro.Conclusion Christina loosestrife herb has a certain effect of lead-eliminating from lead-exposed rats without any obvious adverse effect on renal function,the mechanism should be researched further.