| 参麦注射液对心衰犬内源性洋地黄样物质组织浓度的影响 |
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| 引用本文： | 王贤良,毛静远,魏广力,张振鹏,王恒和,毕颖斐,郭永铁.参麦注射液对心衰犬内源性洋地黄样物质组织浓度的影响[J].中医药研究,2012(1):68-69. |
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| 作者姓名： | 王贤良 毛静远 魏广力 张振鹏 王恒和 毕颖斐 郭永铁 |
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| 作者单位： | [1]天津中医药大学第一附属医院,天津300193 [2]天津药物研究院 ,天津300193 [3]中国中医科学院广安门医院 ,天津300193 [4]天津中医药大学,天津300193 |
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| 基金项目： | 为国家自然科学基金资助项目（No.30371752） |
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| 摘 要： | 目的考察参麦注射液对心衰犬组织内源性洋地黄样物质（EDLS）浓度的影响。方法将造模成功4周后的心衰犬6只,随机分为对照组和参麦注射液组,每组3只。对照组予生理盐水20mL,参麦注射液组予参麦注射液1.551mL/kg（用生理盐水稀释至20mL）静脉注射。给药后4h处死实验犬,分别摘取分离心肌、肾上腺和下丘脑,制成生理盐水匀浆冰冻保存（-80℃）,用放射免疫分析法检测匀浆中的EDLS浓度。结果参麦注射液组肾上腺、下丘脑的EDLS浓度高于对照组,心肌EDLS浓度有高于对照组的趋势。结论参麦注射液可增加心衰犬肾上腺、下丘脑、心肌EDLS浓度。
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| 关 键 词： | 参麦注射液 心力衰竭 内源性洋地黄样物质 |
The Influence of Shenmai Injection on Tissue Concentration of Endogenous Digitalis-like Substance in Dogs with Heart Failure |
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| Institution: | Wang Xianliang,Mao Jingyuan,Wei Guangli,et alFirst Teaching Hospital of Tianjin University of Traditional Chinese Medicine(Tianjin 300193) |
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| Abstract: | Objective To investigate effect of Shenmai injection（SMI） on tissue concentration of endogenous digitalis-like substance（EDLS） in the model dogs with heart failure（HF）.Methods Six model dogs with HF were randomly divided into two groups：Control group（n=3） received intravenous injection of normal saline 20 mL and SMI group（n=3） received intravenous injection of SMI（1.551 mL/kg）.All dogs were executed at 4 h after administration.The homogenate of samples of heart,adrenal gland and hypothalamus were frozen（at-80 ℃）.The EDLS concentrations in tissue samples were determined by radio-immunity assay.Results EDLS concentration of adrenal gland and hypothalamus in SMI group were significantly higher than that in control group.Conclusion SMI could increase the EDLS concentration of adrenal gland,hypothalamus and heart in the model dogs with HF. |
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| Keywords: | Shenmai injection heart failure endogenous digitalis-like substance |
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