腺病毒为载体的单纯疱疹病毒胸苷激酶/更昔洛韦系统联合光动力治疗口腔恶性肿瘤的初步观察

目的应用腺病毒为载体的单纯疱疹病毒胸苷激酶（ADV-TK）/更昔洛韦（GCV）系统联合光动力疗法对口腔恶性肿瘤复发患者进行治疗，探讨此法治疗口腔恶性肿瘤的临床效果。方法选取10名口腔不同部位的恶性肿瘤复发患者，用光敏剂---血卟啉衍生物（HPD）静脉给药，选择相应激光输出功率定时照射，以ADV-TK基因行瘤体及周边注射，经GCV静脉输入治疗后，通过影像学及瘤体血流动力学分析进行临床疗效评估。结果经联合法治疗后，患者肿瘤明显缩小（甚至完全消失），瘤体内血流量降低，影像结果对比改变明显，治疗效果理想。结论将ADV-TK/GCV系统联合光动力治疗口腔恶性肿瘤具有显著的抗肿瘤效应，具备副作用轻微、临床安全性高的特点，为系统性治疗相关肿瘤提供了一种安全可靠的治疗手段。

The initial observation of adenovirus vector-mediated herpes simplex virus-thymidine kinase gene/ganciclovir system and photodynamic therapy for oral malignant tumor treatments

Objective To evaluate the method of adenovirus vector-mediated herpes simplex virus-thymidine kinase gene（ADV-TK）/ganciclovir（GCV） system and photodynamic therapy（PDT） for treating the oral malignant tumor. Methods Ten patients who were suffering from oral malignant tumor of the different positions were selected, and injected with the hematoporphyrin derivative（HPD）, irradiated by picking the corresponding laser frequency, and injected the ADV-TK gene into the tumor body and periphery. By the imaging and the hemodynamics analysis, the clinical efficacy after infusing vein with GCV was assessed. Results After the combination method treatments, patients’tumors appeared clear shrinkage or complete extinction. There was obvious fall of the blood flow volume in the tumor body. Imaging results showed significantly differences. So it was a perfect and effective treatment. Conclusion There are many advantages to apply the ADV-TK/GCV system and PDT treatment on the oral malignant tumor, minimal side effects and greater clinical security. It is a safe and credible therapy which can be offered for curing the oral malignant tumor systematically.