玉米须多糖的止血作用研究

目的:观察玉米须多糖(SMPS)的止血作用并初步探讨其作用机制.方法:分别采用断尾法、玻片法、复钙法观察SMPS对小鼠出血时间(BT)、凝血时间(CT)、血浆复钙时间(RT)的影响；采用血凝仪观察SMPS对大鼠血浆凝血酶原时间(PT)、活化部分凝血活酶时间(APT)、纤维蛋白原(FIB)、血小板聚集性的影响；采用优球蛋...

A study on hemostatic effect of stigma maydis polysacc haride

Objective: To explore hemostatic effect and mechanisms of Stigma Maydis Polysacc haride(SMPS). Methods: Bleeding time(BT),coagulation time(CT),recalcification time(RT) were measured in mice by means of tail cutting,glass slide,recalcification method in mice.Platelet count,the prot hrombin time(PT),the active partial thromboplastin time(APTT) and fibrinogen(FIB),platelet aggregation were measured by means of blood coagulation analyzer and apparatus of platelet aggregation analyzer on rats.The effect of SMPS on fibrinolytic activity was observed by measuring the time of fibrionolysin dissolving. Results: SMPS shortened BT,CT,RT in mice and shortened APTT in rats.SMPS increased the count of Plt,aggregation ability of platelet,and had no effect on PT,FIB,abdomen capillary permeability and the time of fibrionolysin dissolving. Conclusion: The results indicate that SMPS has remarkable effect on hemostasis.Its mechanism is related to increasing platelet count,activating endogenous coagulatian system function,promoting platelet aggregation.