| 柚皮苷抗炎镇痛作用的实验研究 |
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| 引用本文： | 谢仁峰,文双娥,李洋,左灿,张坚松. 柚皮苷抗炎镇痛作用的实验研究[J]. 湖南师范大学学报(医学版), 2011, 8(4): 5-8,12 |
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| 作者姓名： | 谢仁峰 文双娥 李洋 左灿 张坚松 |
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| 作者单位： | 湖南师范大学医学院,湖南长沙,410006 |
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| 基金项目： | 湖南省大学生研究性学习和创新性实验项目 |
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| 摘 要： | 目的:观察柚皮苷的抗炎镇痛作用,初步探讨其抗炎作用机制.方法:在小鼠采用腹腔注射乙酸造成急性疼痛、二甲苯导致急性耳肿胀实验和腹腔毛细血管通透性实验模型,观察柚皮苷的抗炎镇痛作用及量效关系.采用大鼠足跖肿胀(蛋清法)实验,测量足跖肿胀度,分光光度法测量组织PGE2水平.结果:柚皮苷能显著减少小鼠扭体次数、耳肿胀度和腹腔渗...
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| 关 键 词： | 柚皮苷 小鼠 大鼠 抗炎作用 |
Study on the antiinflammation and analgesia of naringin |
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| Xie Renfeng , Wen Shuange , Li Yang , Zuo Can , Zhang Jiansong. Study on the antiinflammation and analgesia of naringin[J]. Journal of Hunan Normal University(Medical Science), 2011, 8(4): 5-8,12 |
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| Authors: | Xie Renfeng Wen Shuange Li Yang Zuo Can Zhang Jiansong |
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| Affiliation: | (Medical College,Hunan Normal University,Changsha 410006,China) |
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| Abstract: | Objective To study the effects of naringin on inflammation or pain.Methods Acetic acid-induced mouse acute pain model was used to compare the analgesic effect of naringin with aspirin.The anti-inflammation effect of naringin(30,60 and 120 mg/kg) was observed on dimethylbenzene-induced auricular edema in mice and fresh egg white induced foot-plate swelling in rats.The OD value of peritoneal washing liquid was observed in acute inflammation model caused by injecting peritoneally 0.6% acetic acid immediately after Evans blue.Results Naringin had significant analgesic effects on acetic acid-induced twisting reaction in mice.Compared w ith the normal control group,the times of twisting decreased significantly in naringin groups(P < 0.05).Conclusion Naringins have the analgesic effects,which may be related to inhibit PGE release. |
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| Keywords: | naringin mice rat anti-inflammation |
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