大肠癌组织中CEA 表达与肝转移的关系

目的：探讨癌胚抗原（CEA）在大肠癌组织中的表达及其与肝转移的关系。 方法：采用免疫组化法分别检测伴肝转移大肠癌的原发灶与肝转移灶、无肝转移大肠癌组织以及正常肠管黏膜组织中CEA的表达，比较CEA在上述4种组织中阳性表达率与表达强度的差异。 结果：伴肝转移大肠癌的原发灶、肝转移灶、无肝转移大肠癌组织中CEA的阳性表达率分别为97.22%、100%、91.67%，均高于正常肠管黏膜组织（19.44%）（均P<0.05）。4种组织之间的CEA表达强度依次为：肝转移灶>伴肝转移大肠癌原发灶>无肝转移大肠癌组织>正常肠管黏膜（均P<0.05）。 结论：大肠癌组织中CEA表达水平可能与其肝转移密切相关；CEA的高表达可能预示大肠癌的肝转移风险增高。

Relationship of CEA expression in colorectal cancer tissue and liver metastasis

Objective: To investigate the carcino-embryonic antigen (CEA) expression in colorectal cancer tissue and its relationship with liver metastasis. Methods: The CEA expressions in the tissues that included the primary lesion and liver metastases of liver metastatic colorectal cancer, and colorectal cancer without liver metastasis as well as normal colorectal mucosa were detected by immunohistochemical staining. The CEA positive expression rates and expression intensities among the above 4 types of tissues were compared. Results: The CEA positive expression rate in the primary lesion and liver metastases of liver metastatic colorectal cancer, colorectal cancer tissue without liver metastasis and normal colorectal tissue was 97.22%, 100%, 91.67% and 19.44% respectively, which were all significantly higher than that in the normal colorectal mucosa (19.44%) (all P<0.05). The CEA expression intensity in a significantly increased to decreased order was: liver metastases, primary lesion of liver metastatic colorectal cancer, colorectal cancer without liver metastasis and normal colorectal mucosa (all P<0.05). Conclusion: The CEA expression level in colorectal cancer tissue may closely be associated with liver metastasis, and high CEA expression of the colorectal cancer tissue may predict an increased risk of liver metastasis.