Palestinian infantile visceral leishmaniasis caused by a genetic variant of Leishmania infantum belonging to a new zymodeme |
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Authors: | Bader Khaldoun A Schnur Lionel F Nasereddin Abedelmajeed Pratlong Francine Dedet Jean-Pierre Shaheen Loay Yousef Obaida Greenblatt Charles L |
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Affiliation: | Department of Parasitology, Hebrew University-Hadassah Medical School, Jerusalem, Israel. |
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Abstract: | The parasites causing a Palestinian case of infantile visceral leishmaniasis (IVL) and those from four dogs from the Jenin District were identified serologically, biochemically and molecular biologically as Leishmania infantum, showing dogs act as a reservoir. The strain from the human case was distinct because of its unique 200-bp kDNA-polymerase chain reaction (PCR) component in its restriction fragment length polymorphism (RFLP) profile after digestion with the endonuclease RsaI, and by the electrophoretic mobility of its malate dehydrogenase (MDH(140)), designating it the reference strain of a new zymodeme of L. infantum, MON-281. |
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Keywords: | Leishmania infantum isoenzyme analysis polymerase chain reaction Palestinian Authority |
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