| 脑缺血后脑组织和血浆中内皮素的变化 |
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| 引用本文： | 张天锡,卞留贯.脑缺血后脑组织和血浆中内皮素的变化[J].中国临床神经科学,1993,1(1):17-19. |
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| 作者姓名： | 张天锡 卞留贯 |
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| 作者单位： | 上海第二医科大学瑞金医院神经外科 (200025)(张天锡，赵卫国)，上海医科大学中山医院 研究生(卞留贯) |
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| 基金项目： | 上海市科委攻关课题基金资助 |
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| 摘 要： | 建立兔大脑中动脉阻断(MCAO)脑缺血模型。将48只兔随机分为四组:C(正常对照和假手术对照组)和脑缺血 I_2、I_4、I_(24)组,每组12只,测脑 H_2O、Na~+、K~+、Ca~(2+)、内皮素(ET)和血浆 ET。结果示脑缺血侧脑皮质和血浆中 ET 含量显著高于对照组(P<0.001),且随时相递增(P<0.01),ET与脑 H_2O 含量之间呈显著正相关(P<0.05),提示 ET 可能参与脑缺血、脑水肿的发生发展。
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| 关 键 词： | 脑缺血 脑水肿 MCAO 内皮素 兔 |
Changes of Endothelin-1 in Cerebral Corfex and Plasma After Cerebral Ischemia |
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| Zhang Tian-Xi.Changes of Endothelin-1 in Cerebral Corfex and Plasma After Cerebral Ischemia[J].Chinese Journal of Clinical Neurosciences,1993,1(1):17-19. |
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| Authors: | Zhang Tian-Xi |
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| Institution: | Zhang Tian-Xi Department of Neurosurgery,Rui-Jin Hospital,SSMU,Shanghai |
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| Abstract: | Using the rabbit middle cerebral artery occlusion(MCAO)model,the con- tent of ET-1 in cerebral cortex and plasma were measured by RIA.48 rab- bits were randomly divided into four groups:control including shamoperated and normal control,2h,4h,24h after cerebral ischemia(I_2, I_4, I_(24)).we found that ET-1 contents were significantly increased compared to control group(p<0.01)and changed much greater with the increasing ischemic ti- me.There were positive correlation between ET-1 and H_2O(p<0.05).These results suggested that ET-1 might take part in the ischemic brain injury and enhanced the ischemic brain edema |
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| Keywords: | Cerebral ischemia Brain Edema endothelin MCAO Rabbit |
| 本文献已被 CNKI 维普 等数据库收录！ |
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