| 抗骨折方促进实验性大鼠骨折愈合作用的研究 |
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| 引用本文： | 沈祥春,张责林,任光友. 抗骨折方促进实验性大鼠骨折愈合作用的研究[J]. 中华中医药杂志, 2007, 22(5): 285-288 |
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| 作者姓名： | 沈祥春 张责林 任光友 |
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| 作者单位： | 贵阳医学院药理研究室,贵阳,550004 |
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| 基金项目： | 贵州省中药现代化科技产业研究开发专项基金 |
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| 摘 要： | 目的：研究抗骨折方对实验性大鼠骨折愈合的作用。方法：采用胫骨骨缺损的方法复制实验性大鼠骨折模型，连续给予抗骨折方21d，以x线片、病理组织学检测以及骨折愈合组织抗折强度为指标观察其疗效。结果：抗骨折方组动物骨折处见骨痂改建较好，骨小梁成熟，周边成骨细胞较多；X线检测结果提示，抗骨折方明显提高骨折组织x线评分，愈合组织抗折强度明显增强；与模型组比较，差异显著。结论：抗骨折方对实验性大鼠骨折损伤模型具有显著的促进愈合作用。
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| 关 键 词： | 抗骨折方 实验性骨折 X线检测 骨折强度 中医药疗法 |
| 修稿时间： | 2006-05-04 |
Effects of Kangguzhe Formula on Promoting Union of Experimental Rat Fracture |
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| Shen Xiangchun,Zhang Guilin,Ren Guangyou. Effects of Kangguzhe Formula on Promoting Union of Experimental Rat Fracture[J]. China Journal of Traditional Chinese Medicine and Pharmacy, 2007, 22(5): 285-288 |
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| Authors: | Shen Xiangchun Zhang Guilin Ren Guangyou |
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| Affiliation: | Research Division of Pharmacology, Guiyang Medical College, Guiyang 550004 |
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| Abstract: | Objective: To investigate the effects of Kangguzhe Formula(KGZF) on promoting union of experimental rat fracture.Methods: The experimental rat fracture models were reproduced by cannon born injure,continually treated with KGZF 21d by oral administration.The X-ray,pathological histology and anti-fracture intension of fracture union tissue were detected to investigate the effects of KGZF.Results: KGZF can significantly improve the osteotylus rebuild,trabeculation of bone and concentrated osteoblasts of fracture tissue;X-ray detection also showed that it can increase the grade of X-ray and anti-fracture intension of fracture union tissue;Compared with model group,it had significant difference.Conclusion: KGZF can obviously improve the union of experimental rat fracture. |
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| Keywords: | Kangguzhe Formula(KGZF) experimental fracture X-ray detection fracture intension TCM therapy |
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