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| 荜茇明碱抗肿瘤作用及其机制 | |
| 引用本文： | 姚志峰,姚建新,刘永彪. 荜茇明碱抗肿瘤作用及其机制[J]. 国际肿瘤学杂志, 2013, 40(4): 259-263 |
| 作者姓名： | 姚志峰 姚建新 刘永彪 |
| 作者单位： | 1. 210029,南京医科大学第一临床医学院肿瘤学系 2. 江苏联合职业技术学院南京卫生分院医学影像系 3. 南京医科大学第一附属医院肿瘤放射治疗科 |
| 基金项目： | 江苏省高校优势学科建设工程(项目编号：JX10231801) |
| 摘 要： | 荜茇明碱是从胡椒科植物中分离出的生物碱(酰胺类)天然产物,具有多种药理作用.近年来研究发现其对多种肿瘤的生长具有抑制作用,是一种潜在的抗肿瘤药物.荜茇明碱能够抑制肿瘤细胞的增殖、诱导细胞周期的阻滞并且促进肿瘤细胞的凋亡.最新的研究表明荜茇明碱的抗肿瘤机制可能与其激活活性氧应激途径密切相关. |
| 关 键 词： | 抗肿瘤药 细胞凋亡 活性氧 荜茇明碱 |
Anti-tumor effect of piplartine and its mechanism |
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| YAO Zhi-feng , YAO Jian-xin , LIU Yong-biao. Anti-tumor effect of piplartine and its mechanism[J]. Journal of International Oncology, 2013, 40(4): 259-263 | |
| Authors: | YAO Zhi-feng YAO Jian-xin LIU Yong-biao |
| Affiliation: | Department of Oncology, First Clinical College of Nanjing Medical University，Nanjing 210029，China |
| Abstract: | Piplartine is an alkaloids/amide component of Piper species, having diverse pharmacological and biological activities. Recent studies have indicated that piplartine has inhibitory effects on several kinds of tumors and is a potential antitumor drug. It can inhibit the proliferation of tumor cells, cause cell cycle arrest and induce apoptosis. More investigations suggest targeting the reactive oxygen species(ROS) stress-response pathway is closely related to its antitumor activity. |
| Keywords: | Antineoplastic agents Apoptosis Reactive oxygen species Piplartine |
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