368例吸烟肺癌患者临床特点与生存分析

目的 探讨总结吸烟肺癌患者的临床特点及其对生存的影响.方法 回顾性分析368例吸烟肺癌患者的临床资料,分析患者的年龄构成、性别比例、组织学分型、临床分期、治疗方法及中医分型等临床指标,分析各指标对生存的影响.结果 368例吸烟肺癌患者中,50～69岁为69.84％；男女比例为7.98∶1;鳞癌比例高达52.45％；小细胞肺癌广泛期患者达75.38％；非小细胞肺癌Ⅲ、Ⅳ期患者达82.77％；非手术者达76.36％；中西医结合治疗者占41.04％；气阴两虚型及热毒炽盛型较多见,分别为36.96％、29.28％.性别、组织学分型、中医分型对生存预后影响不明显,而年龄(F=10.356,P=0.000)、临床分期(F=11.289,P=0.000)、治疗方法(t=2.624,P=0.021)、吸烟指数(F=3.681,P=0.021)对生存预后有影响.结论 368例吸烟肺癌患者发病多集中在50 ～69岁,男性、鳞癌为多,就诊时多为中晚期,非手术治疗为主,且年龄、临床分期、治疗方法与吸烟指数可影响患者生存预后.

Clinical characteristics and survival analysis of 368 cases of smoking lung cancer patients

Objective To discuss the clinical characteristics and the relationship with the survival of smoking lung cancer patients. Methods The clinical data of 368 cases were retrospectively analyzed by comparing the differences of the age, gender, histological type, clinical stage, treatment and symptoms of tradition Chinese medicine, and their correlation with the survival was analyzed. Results: Among the 368 patients, the ones aged between 50 to 69 accounted for 69.84%; the proportion between the male ones and the female ones was 7.98:1; the proportion of the squamous cell carcinoma was as high as 52.45%; the proportion of the patients with small cell lung cancer in extensive stage was significantly higher than that of the patients in the limited stage(75.38% vs 24.62%); the numbers of the patients with non-small cell lung cancer in stage Ⅲ and Ⅳ was significantly higher than that in the stageⅠandⅡ(82.77% vs 17.23%); the ones with non-surgical treatment accounted for 76.36%, and the proportion of ones with surgery treatment were 23.64%; most of the patients were treated by both Chinese medicine and chemotherapy(41.04%); the main types of all patients were qi-yin deficiency syndrome and toxic heat flourishing syndrome, accounting for 36.96% and 29.28% respectively. The age（F=10.356，P=0.000）, clinical stage（F=11.289，P=0.000）, treatment methods（t=2.624，P=0.021）, smoking index（F=3.681，P=0.021） were the key factors effecting the survival (P＜0.05), and the gender, histological type, tradition Chinese medicine type had no significant effect（P＞0.05）.Conclusion The clinical characteristics of the cases are 50-69-aged, male, squamous cell carcinoma, advanced stage, treatment without surgery. The survival of smoking lung cancer patients is effected by the age, clinical stage, treatment methods and smoking index.