动脉瘤性蛛网膜下腔出血患者血清垂体激素含量变化的动态研究

目的：研究动脉瘤性蛛网膜下腔出血(SAH)患者血清促肾上腺皮质激素（ACTH）、促甲状腺激素（TSH）、卵泡刺激素（FSH）、黄体生成素（LH）、泌乳素（PRL）、生长激素（GH）浓度的动态变化规律。方法：对35例动脉瘤性SAH患者发病后1～3?d、7～9?d、13～15?d血清ACTH、TSH、FSH、LH、PRL、GH进行动态观察, 用TCD检测大脑中动脉血流速度(VMCA)。结果：动脉瘤性SAH患者血清ACTH、TSH、FSH、LH、PRL、GH发病后1～3?d、7～9?d各均值明显高于对照组（P均＜0.05），尤以发病后7～9?d变化最明显（P＜0.01）；脑血管痉挛组较非脑血管痉挛组也有明显差异（P＜0.05）。结论：动脉瘤性SAH患者血清ACTH、TSH、FSH、LH、GH、PRL含量与病情演变、脑血管痉挛程度有关。

Dynamical changes of the serum concentration of pituitary hormone in patients with aneurysmal subarachnoid hemorrhage

Objective:To investigate the relationship between the serum concentration of ACTH,TSH,FSH,LH,PRL and GH and the subarachnoid hemorrhage.Methods: The serum concentrations of ACTH,TSH,FSH,LH,PRL and GH at 1-3 days,7-9 days,and 13-15 days after seizures were detected in 35 patients.The VMCA was detected by TCD.Results: All the indexes at 1-3 days,7-9 days after seizures significantly highered.The indexes at 7-9 days after seizures the most significantly highered. All the indexes of cerebral vasospasm(CVS) patients were markedly different from those of non-CVS patients.Conclusion: These findings suggest that there is a positive correlation between the serum concentration of ACTH,TSH,FSH,LH,PRL and GH and the symptom of CVS.