胰腺癌术中组织活检及细胞学诊断的临床意义

目的 探讨胰腺癌术中组织活检和细胞学诊断的临床应用价值.方法 回顾性分析术中行组织活检和穿刺细胞学检查的142例胰腺癌患者的临床资料.142例患者均获得组织病理学诊断,其中80例患者术中行快速冰冻切片病理检查,87例患者术中行穿刺细胞学检查.结果 术中组织活检诊断准确率为83.8%,穿刺细胞学检查诊断准确率为93.1%,差异有统计学意义(P=0.027).术中组织活检和穿刺细胞学检查均无相关并发症发生.结论 胰腺癌组织学诊断困难,术中行组织活检或穿刺细胞学检查安全性和诊断准确率均较高,是提高胰腺癌诊断的有效方法.

Value of intraoperative fine-needle aspiration cytology and histopathologic biopsy in the diagnosis of pancreatic cancer

OBJECTIVE: To investigate the clinical value of intraoperative aspiration cytology and histopathologic biopsy in the diagnosis of pancreatic cancer. METHODS: 142 patients with suspected pancreatic carcinoma underwent surgical exploration and the data were retrospectively analyzed. Chi-square test (chi2) was used to compare the accuracy between fine-needle aspiration cytology and histopathologic biopsy. RESULTS: Of the 192 patients with suspected pancreatic carcinoma, 80 were confirmed by histological biopsy and 87 by fine-needle aspiration cytology, with an accuracy rate of 83.8% and 93.1%, respectively. There was a statistically significant difference between these two groups (P = 0.027). No perioperative surgical complication was observed in this series. CONCLUSION: Intraoperative aspiration cytology and histopathologic biopsy was safe and helpful with a high accuracy for the diagnosis of pancreatic carcinoma.