Urinary prostacyclin metabolites in patients with IgA nephropathy |
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Authors: | T Morita Hiroyuki Ito Tadashi Suehiro Masui Kawada Kaoru Arii Kiyoshi Tahara Naoko Hisakawa Yukio Ikeda Koji Nishiya Kozo Hashimoto |
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Institution: | (1) Second Department of Internal Medicine, Kochi Medical School, Kohasu, Okoh-cho, Nankoku, Kochi 783-8505, Japan Tel. +81-888-80-2343; Fax +81-888-80-2344 e-mail: morita@med.kochi-ms.ac.jp, JP |
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Abstract: | Background. Urinary 6-keto-prostaglandin F1α (6kPGF) is an index of renal prostacyclin (PGI2) synthesis, while urinary 2,3-dinor-6-keto-prostaglandin F1α (23d6kPGF) reflects extrarenal PGI2 synthesis. We therefore examined the relationship between the urinary excretion of PGI2 metabolites and the deterioration of renal function and histopathological findings.
Methods. We measured these PGI2 metabolites in 24-h collected urine from 32 patients with IgA nephropathy (IgAN) and 24 normal controls.
Results. The urinary 6kPGF excretion in all patients (790 ± 395 pg/mg creatinine Cr]) did not differ significantly from that in the
normal controls (896 ± 351 pg/mgCr), but it was decreased in the patients with histopathological deterioration (661 ± 281
pg/mgCr). There were no such findings for 23d6kPGF. In the IgAN patients, the urinary 6kPGF excretion demonstrated a positive
correlation to the 1/creatinine slope, which indicated deterioration of renal function (r = 0.43; P < 0.03).
Conclusions. Renal PGI2 production is reduced in IgAN patients with histopathological deterioration, and 24-h urinary 6kPGF excretion may be an effective
marker to evaluate the renal injury.
Received: June 22, 1998 / Accepted: December 19, 1999 |
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Keywords: | Prostaglandin Renal histopathology Renal dysfunction 2 3-Dinor-6-keto-prostaglandin F1α 6-Keto-prostaglandin F1α |
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