| 人类白细胞抗原G在恶性黑色素瘤中的表达及其与孕激素受体的关系 |
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| 引用本文： | 方险峰,鲍五一,李家文. 人类白细胞抗原G在恶性黑色素瘤中的表达及其与孕激素受体的关系[J]. 武汉大学学报(医学版), 2009, 30(2): 242-244,插3 |
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| 作者姓名： | 方险峰 鲍五一 李家文 |
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| 作者单位： | 华中科技大学同济医学院附属协和医院皮肤科,湖北,武汉,430022;湖北省枝江市中医院,湖北,枝江,443200 |
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| 摘 要： | 目的:探讨人类白细胞抗原-G(HLA-G)在原发性皮肤黑色素瘤(CMM)中的表达情况及其与孕激素受体(PR)表达的关系。方法:以免疫组化法检测35例原发性CMM、12例痣细胞痣(6例炎性痣细胞痣,6例普通痣细胞痣)HLA-G及PR的表达,并结合临床及组织病理学资料进行分析。结果:HLA-G与PR均在CMM中选择性表达。HLA-G蛋白表达与肿瘤微环境炎细胞浸润显著相关。PR表达在女性、年龄≤55岁、病程>1年、溃疡以及非肢端型组织亚型的阳性比例增高,但均无统计学意义。HLA-G与PR在CMM中的表达无显著相关。结论:HLA-G在CMM中的表达调节可能与肿瘤微环境中宿主抗肿瘤免疫反应有关,而与孕激素无关。
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| 关 键 词： | 原发性皮肤黑色素瘤 人类白细胞抗原-G 孕激素受体 |
Expression of Human Leukocyte Antigen G in Primary Cutaneous Malignant Melanoma and Its Correlation with Progesterone Receptor |
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| FANG Xianfeng,BAO Wuyi,LI Jiawen. Expression of Human Leukocyte Antigen G in Primary Cutaneous Malignant Melanoma and Its Correlation with Progesterone Receptor[J]. Medical Journal of Wuhan University, 2009, 30(2): 242-244,插3 |
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| Authors: | FANG Xianfeng BAO Wuyi LI Jiawen |
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| Affiliation: | FANG Xianfeng1,BAO Wuyi2,LI Jiawen1 1Dept.of Dermatology,Affiliated Union Hospital,Tongji Medical College,Huazhong University of Science , Technology,Wuhan 430022,China 2Zhijiang Traditional Chinese Medicine Hospital,Zhijiang 443200,China |
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| Abstract: | Objective: To investigate the expression of human leukocyte antigen G(HLA-G) in primary cutaneous malignant melanoma(CMM) and the correlation with progesterone receptor(PR) expression.Methods: HLA-G antigen and PR expression in a series of 47 skin melanocytic lesions were evaluated by immunohistochemistry.Results: Selective HLA-G and PR expression was detected in CMM.HLA-G expression was significantly correlated with the inflammatory infiltration,whereas no significant correlations with ulceration,tumor thi... |
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| Keywords: | Cutaneous Malignant Melanoma Human Lukocyte Antigen G Progesterone Receptor |
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