| Changes of 5－hydroxytryptamine and dopamine contents in brain microvessels and the influence on cerebral edema at early stage |
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| 引用本文： | 柯以铨,徐如祥,陈长才.Changes of 5－hydroxytryptamine and dopamine contents in brain microvessels and the influence on cerebral edema at early stage[J].中国人民解放军军医大学学报,1995(2). |
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| 作者姓名： | 柯以铨 徐如祥 陈长才 |
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| 作者单位： | Department of Neurosurgery，Zhujiang Hospital，First Military Medical Universily，Guangzhou，510282 |
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| 摘 要： | Ｃｈａｎｇｅｓｏｆ５－ｈｙｄｒｏｘｙｔｒｙｐｔａｍｉｎｅａｎｄｄｏｐａｍｉｎｅｃｏｎｔｅｎｔｓｉｎｂｒａｉｎ ｍｉｃｒｏｖｅｓｓｅｌｓａｎｄｔｈｅｉｎｆｌｕｅｎｃｅｏｎｃｅｒｅｂｒａｌｅｄｅｍａａｔｅａｒｌｙｓｔａｇｅｏｆｂｒａｉｎｉｎｊｕｒｙＫｅＹ...
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Changes of 5-hydroxytryptamine and dopamine contents in brain microvessels and the influence on cerebral edema at early stage of brain injury |
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| Ke Yiquan,Xu Ruxiang,Chen Changcai.Changes of 5-hydroxytryptamine and dopamine contents in brain microvessels and the influence on cerebral edema at early stage of brain injury[J].Journal of Medical Colleges of PLA(China),1995(2). |
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| Authors: | Ke Yiquan Xu Ruxiang Chen Changcai |
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| Abstract: | The contents of 5-hydroxytryptamine(5-HT)and dopamine(DA) in the brain microvessels(BMVs) at the early stage of rat brain injury were measured by using high performance liquid chromatography with electrochemical detector(HPLC-ECD) and the influence of the 5-HT and DA level changes on cerebral edema was studied.The results showed that the levels of 5-HT and DA in the BMVs increased apparently at 0.5h,and were still higher than the control value at 6h after brain injury(P<01).The brain water content increased remarkably in the same time.The results indicate that the increment of 5-HT and DA in the BMVs might be one of the most important factors in the production and development of traumatic brain edema following brain injury. |
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| Keywords: | brain injury brain edema 5-hydroxytryptamine dopamine brain microvessels |
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