| 复方阿仑膦酸钠缓释片的制备及体外释放度考察 |
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| 引用本文： | 龙明立,贺丽平,曾建国.复方阿仑膦酸钠缓释片的制备及体外释放度考察[J].中国药房,2008,19(34):2690-2692. |
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| 作者姓名： | 龙明立 贺丽平 曾建国 |
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| 作者单位： | 长沙市中心医院临床药学研究室，广东省东莞裕元医院 |
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| 摘 要： | 目的:制备复方阿仑膦酸钠缓释片并考察其体外释放度。方法:以羟丙基甲基纤维素(HPMC)、乙基纤维素(EC)、无水乳糖处方用量为因素,体外释放度为指标,用正交试验优化处方,以湿法制粒压片制备制剂,并考察其体外释放度。结果:筛选最优处方为HPMC 80mg、EC 20mg、无水乳糖20mg。所制制剂可持续12h释药,释放行为符合Higuchi方程。结论:所制缓释片的处方合理,具有良好的缓释效果。
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| 关 键 词： | 阿仑膦酸钠 缓释片 正交设计 体外释放度 |
Preparation and Release of Compound Alendronate Sodium Sustained-release Tablet in Vitro |
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| LONG Ming-li,ZENG Jian-guo.Preparation and Release of Compound Alendronate Sodium Sustained-release Tablet in Vitro[J].China Pharmacy,2008,19(34):2690-2692. |
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| Authors: | LONG Ming-li ZENG Jian-guo |
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| Institution: | LONG Ming-li, ZENG Jian-guo,HE Li-ping(1.Clinical Pharmacy Research Institute, Changsha Municipal Central Hospital, Changsha 410004, China;2.Guangdong Dongguan Municipal Yuyuan Hospital, Dongguan 523286, China) |
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| Abstract: | OBJECTIVE:To prepare compound alendronate sodium sustained-release tablet and to investigate its drug release profile in vitro. METHODS: Hydroxy propyl methylcellulose (HPMC), ethylcellulose (EC), and lactis anhydrous were used to prepare sustained-release tablets by wet granule compression technique with release rate in vitro as index. Orthogonal experiment was conducted to optimize the formula. The release rate of the tablets in vitro was investigated. RESULTS: The optimized formula was as follows: HPMC 80 mg, EC 20 mg, and lactis anhydrous 20 mg. 12 h drug release of the preparation was achieved, and the drug release behavior in vitro fitted Higuchi equation. CONCLUSION: The sustained-release tablet is reasonable in formula and satisfactory in slow release efficacy. |
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| Keywords: | Alendronate sodium Sustained-release tablet Orthogonal design Release rate in vitro |
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