| 左旋四氢帕马汀在大鼠急性全脑缺血再灌注时对能量代谢内皮素—1及一氧化氮的影响 |
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| 引用本文： | 蒋崇慧,杨光田,汤彦,邓普珍. 左旋四氢帕马汀在大鼠急性全脑缺血再灌注时对能量代谢内皮素—1及一氧化氮的影响[J]. 中国急救医学, 2001, 21(6): 317-318 |
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| 作者姓名： | 蒋崇慧 杨光田 汤彦 邓普珍 |
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| 作者单位： | 1. 广东省中山市人民医院急救中心,
2. 同济医科大学附属同济医院急诊科, |
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| 摘 要： | 目的：了解左旋四氢帕马汀（L-THP)在大鼠急性全脑缺血再灌注损伤中对一氧化氮（NO）、内皮素－1（ET－1）、三磷酸腺苷（ATP）及乳酸的影响，探讨L－THP对脑缺血再灌注损伤的保护作用。方法：采用Pulsinelli方法建立大鼠急性全脑缺血再灌注损伤模型，观察L－THP在再灌注期间对NO、ET－1及能量代谢的影响。结果：L－THP可抑制再灌注早期NO、ET－1及乳酸的过量产生，提高ATP含量。结论L－THP可以通过对NO、ET－1及能量代谢的影响对大脑起保护作用。
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| 关 键 词： | 脑缺血 再灌注损伤 左旋四氢帕马汀 能量代谢 一氧化氮 内皮素－1 |
| 文章编号： | 1002-1949(2001)06-0317-02 |
| 修稿时间： | 2000-12-27 |
Effects of L-Tetrahydropalmatine(L-THP) on energy metabolism,endothelin-1 and NO during acute cerebral ischemia-reperfusion of rats |
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| Abstract: | Objective To find the influence of L_Tetrahydropalmatine(L-THP)on NO,ET_1,ATP and Lactate in the brain tissues after the global ischemia_reperfusion of rats and the protective effects of L_THP were also observed.Methods The four_vessel occlusion models was made as discribedd by pulsinelli.Observing the influencce of L_THP on NO,ET_1 and energy metabolism during the reperfusion period.Results L_THP can depress the marked increase of NO,ET_1 and lactate in the early stage of reperfusion,and also improve the contents of ATP.Conclusions L_THP have a remarkble protection on cerebral ischemia_reperfusion damage.Its mechanisms may be imvoloved in the influence of L_THP on NO,ET_1 and energy metabolism. |
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| Keywords: | Cerebral ischemia_reperfusion damage L_Tetrahydropalmatine Nitric oxide Endothelin_1 Energy Metabolism |
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