| 房颤大鼠血清MMP-9的水平及定心胶囊干预作用 |
| |
| 引用本文： | 季芳,张艳. 房颤大鼠血清MMP-9的水平及定心胶囊干预作用[J]. 中华中医药学刊, 2007, 25(3): 518-520 |
| |
| 作者姓名： | 季芳 张艳 |
| |
| 作者单位： | 辽宁中医药大学,辽宁,沈阳,110032 |
| |
| 摘 要： | 目的：探讨大鼠房颤后血清MMP-9的水平改变及定心汤对其调节作用。方法：采用健康雄性Wistar大鼠。首先建立慢性房颤的动物模型。将造模成功的大鼠设模型组、正常对照组、西药对照纽和定心胶囊治疗组。用药4周后，观察定心胶囊中药组和西药维拉帕米对房颤大鼠血清中MMP-9的影响。结果：①大鼠房颤模型组与正常对照组比较，血清中MMP-9的含量明显增加（P〈0．05）。②定心胶囊治疗组和维拉帕米对照组与模型组比较，可以明显地降低血清中MMP-9的含量（P〈0．05）。③定心胶囊治疗组与维拉帕米对照组对房颤大鼠血清中MMP-9的改善程度相比前者优于后者（P〈0．05），有统计学意义。④同时模型组与正常组比较，心肌细胞超微结构有严重损伤，说明房颤大鼠的模型基本建立成功，治疗组对心肌细胞超微结构改善明显，其中以中药组尤为突出。结论：定心胶童可以抑制庚颤血清MMP-9的水平．是防治庚颤的有效药物．
|
| 关 键 词： | 定心胶囊 房颤 |
| 文章编号： | 1673-7717（2007）03-0518-03 |
| 收稿时间： | 2006-10-10 |
| 修稿时间： | 2006-10-10 |
Expression of Serum MMP-9 in Rats During the Atrial Fibrillation and the Influence of Dingxin Capsule for Recuperation on It |
| |
| JI Fang,ZHANG Yan. Expression of Serum MMP-9 in Rats During the Atrial Fibrillation and the Influence of Dingxin Capsule for Recuperation on It[J]. Chinese Archives of Traditional Chinese Medicine, 2007, 25(3): 518-520 |
| |
| Authors: | JI Fang ZHANG Yan |
| |
| Affiliation: | Liaoning Universrsity of TCM, Shenyang 110032, Liaoning, China |
| |
| Abstract: | Objective:To explore the expression of serum metalloproteinase-9(MMP-9)in Rats during the Atrial fibrillation(AF)and the influence of Dingxin capsule for Recuperation on it.Methods:The healthy male Wistar Rats were used.The rats were randonmize to 4 groups: normal control group,model group,Dingxin capsule group,Verpamil intervention group.The level of MMP-9 of AF rats were measured.Results: With the comparison of treating group and model group,the level of MMP-9 in treating group lowed obviously(P<0.05).Both of them had statistic significance.Both Dingxin capsule group and Verpamil intervention group could low the level of MMP-9,but Dingxin capsule group is better.Conclusion:MMP-9 played important role in the pathogenesis of AF.Dingxin capsule could correct the level of MMP-9 in AF rats. |
| |
| Keywords: | MMP-9 |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
