Inappropriate left ventricular mass changes during treatment adversely affects cardiovascular prognosis in hypertensive patients |
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Authors: | Muiesan Maria Lorenza Salvetti Massimo Paini Anna Monteduro Cristina Galbassini Gloria Bonzi Bianca Poisa Paolo Belotti Eugenia Agabiti Rosei Claudia Rizzoni Damiano Castellano Maurizio Agabiti Rosei Enrico |
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Institution: | Department of Medical and Surgical Sciences, University of Brescia, 25100 Brescia, Italy. muiesan@med.unibs.it |
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Abstract: | Inappropriate left ventricular mass (LVM; ie, the value of LVM exceeding individual needs to compensate hemodynamic load) predicts the risk of cardiovascular (CV) events, independent of risk factors, either in the presence or in the absence of traditionally defined LV hypertrophy. The relation between changes in appropriateness of LVM during antihypertensive treatment and subsequent prognosis was evaluated in 436 prospectively identified uncomplicated hypertensive subjects, with a baseline and follow-up standard clinical evaluation, laboratory examinations, and echocardiogram (last examination: 6+/-3 years apart), followed for additional 4.5+/-2.5 years. The appropriateness of LVM to cardiac workload was calculated by the ratio of observed LVM to the value predicted for individual sex, height, and stroke work at rest. At baseline, low or appropriate LVM (
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