血管性痴呆与同型半胱氨酸水平的相关性研究

目的 探讨血浆同型半胱氨酸（Hcy）水平与血管性痴呆（VD）的相关性.方法 检测37例VD患者的血浆Hcy浓度,并与39例非痴呆脑梗死患者作为同期对照组血浆Hcy浓度进行比较,根据简易精神状态检查量表（MMSE）评分划分VD患者严重程度,分为轻度（20～24分）,中度（10～19分）,重度（10分以下）.结果VD组血浆Hcy水平显著高于非痴呆脑梗死组（P＜0.01）,不同程度VD患者血浆Hcy水平有显著性差异（P＜0.05）.结论 高同型半胱氨酸血症与VD发病密切相关,而且同型半胱氨酸水平越高,血管性痴呆的程度越严重.

Clinical Studies on the Relations Between the Vascular Dementia and Homocysteine Levels

Objective To study the relationship between vascular dementia and plasma homocysteine. Methods 37vd patients and 39 patients with nondemented cerebral infarction were recruite in the study. the severityof cognition impairment in VD patients was classified by MMSEs ＇ scores： mild （20 - 24 points）, moderate （10-19） and severe（ 〈 10）. Result mean total plasma hey concentrations were significantly higher in VD patients with nondemented cerebral infarction （ P 〈 0. 01. Plasma Hcy was different significantly in VD patients with different severities of cognition impairment （ P 〈 0. 05） . Conclusion Hyperhomocysteinemia has significant correlation with VD. The level of dementia conitive impairment aggregated with the increase of serum Hcy level.