盐酸小檗碱片联合四联疗法根治幽门螺杆菌的疗效观察

目的:对比盐酸小檗碱片联合四联疗法和四联疗法根除幽门螺杆菌(Hp)方案的临床效果,为临床治疗方案的选择提供参考。方法:将160例幽门螺杆菌阳性消化性溃疡患者随机分为两组。A组:口服埃索美拉唑(20 mg)+阿莫西林(1.0 g)+枸橼酸铋钾(220 mg)+克拉霉素(0.5 g),每日2次,服用10 d。B组:口服埃索美拉唑(20 mg)+枸橼酸铋钾(220mg)+阿莫西林(1.0g)+克拉霉素(0.5g),每日2次,盐酸小檗碱片300 mg,每日3次,服用10 d。观察记录Hp根除情况及不良反应。结果:两组Hp根除率分别为81.23%和87.50%,差异有统计学意义(P<0.05)。两组不良反应率比较,差异无统计学意义(P<0.05)。结论:盐酸小檗碱片联合铋剂四联组不良反应未明显增加,根除率更高,是较理想的治疗方案。

The effect observation on berberine hydrochloride tablets combined quadruple chemotherapy for the eradication of helicobacter pylori

Objective ：To compare the clinical effect of berberine hydrochloride tablets combined quadruple chemotherapl for the eradication of helicobacter pylofi（Hp） ,provide reference for the choice of treatment. Methods：A total of 160 patient with helicobacter pylori positive peptic ulcer disease were dvided into two groups . The group A ： take orally esomeprazoh （20 rag） ＋ amoxicillin（ 1.0 g） ＋ colloidal bismuth subcitrate （220 rag） ＋ clarithromycin （0.5 g）, 2 times per day, for teJ days. The group B ： take orally esomeprazole （ 20 rag） ＋ colloidal bismuth subcitrate （ 220 rag） ＋ amoxicillin （ 1.0 g） ＋ clarithro mycin（0.5 g） ,2 times per day, ＋ berberine hydrochloride tablets（300 rag） ,3 times per day,for ten days. To observe and re cord the eradication and adverse reactions of Hp. Results：The total eradication rate of HP of the group A were 81.23%. Th total eradication rate of HP of the group B were 87.50% , siginificantly higher than the group A, the difference was statistieall siginifiant（ P 〈 0.05 ）. The incidence adverse reactions of group B and group A were simler. The difference was not statisticall siginifieant （P 〉 0.05 ）. Conclusion ： Bismuth agent four transmitte adverse reactions did not significantly increased, the eradica tion rate is higher,is the ideal reatment.