血卟啉单甲醚声动力疗法对兔耳增生性瘢痕的疗效

目的观察血卟啉单甲醚声动力疗法对兔耳增生性瘢痕（hyperplastic scar，HS）的疗效。方法成年大耳白兔60只，随机分成5组。在声动力治疗第2、4、6、8周分别切取两组瘢痕组织，进行指标检测。结果治疗组可降低成纤维细胞密度、瘢痕增生指数，与模型对照组比较差异有统计学意义（P〈O．05），可降低胶原纤维的面密度，从上皮化后第4周开始与模型组比较差异有统计学意义（P〈O．01）。结论声动力效应能够显著降低兔耳HS，可望为HS治疗提供新的手段。

Effects of HMME-SDT on hypertrophic scar of rabbit ear

Objective To observe the clinical efficacy of HMME-SDT therapy for the treatment of hypertrophic scar （HS） of rabbit ear. Methods 60 white rabbits were randomly divided into five groups. The model group and HMME-SDT treatment group were used to establish the models of hy pertrophic scar in ears. Results The effect of HMME-SDT on the fibroblastie density in the hyper trophic scarring models was observed in rabbit ears. The HMME-SDT could lower the fibroblastic density, compared with the model group, with significant difference （P（0. 05）. The effect of HMME-SDT on the collagen area density was noted in the hypertrophic scarring models in rabbit ears. The HMME-SDT could lower the collagen area density, compared with the model group, with signifi cant difference from the fourth week of the epithelialization （P~0.0l）. Conclusions HMME is an ef fective sonosensitizer. HMME-SDT can significantly inhibit hypertrophic scar of rabbit ear.