参麦注射液对垂体后叶素诱发小鼠心肌缺血的保护作用

目的: 观察参麦注射液对心肌缺血的保护作用。方法: 实验动物随机分为两组,参麦注射液组:参麦注射液0。2 ml/10 g腹腔注射,每天2次;缺血组:生理盐水0。2 ml/10 g腹腔注射,每天2次,3天后腹腔注射垂体后叶素20 u/kg诱导急性心肌缺血;观察心电图变化(J点改变及心率变化)。结果: 与缺血组比较,参麦注射液明显减少心肌缺血心脏的心电图J点的抬高幅度(P<0。01),并能抑制心肌缺血所致的心率减慢(P<0。01)。结论: 参麦注射液有预防缺血性损伤、保护心脏的作用。

Protective effect of Shenmai injection on pituitrin-induced myocardial ischemic injury in mice

Objective:To observe the protective effect of Shenmai on the myocardial ischemic injury in mice.Methods:The experimental animals were divided into two groups randomly.In the Shenmai group,the mice were injected Shenmai intraperitoneally twice a day(0.2 ml/10 g,ip).In the ischemic group,the mice were given normal saline twice a day(0.2 ml/10 g,ip).Three days later,pituitrin(20 u/kg) was injected intraperitoneally to induce myocardial ischemic injury.The electrocardiogram was recorded.Results:Shenmai injection reduced the rise amplitude of J spot in electrocardiogram( P <0.01).The heart rate of Shenmai group did not significantly slow down( P < 0.01 ).Conclusions:These results demonstrate that Shenmai injection can protect myocardium from ischemic injury.