Effects of medial raphe and raphe magnus lesions on the analgesic activity of morphine and methadone |
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| Authors: | William T. Chance Glenn M. Krynock John A. Rosecrans |
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| Affiliation: | (1) Department of Pharmacology, Medical College of Virginia, Virginia Commonwealth University, MCV Station, Box 726, 23298 Richmond, Virginia, USA |
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| Abstract: | The effects of lesions of the raphe nuclei on opiate-induced antinociception and brain serotonin (5-HT) levels were investigated. Lesions of the medial raphe nucleus effectively antagonized the analgesic effects of morphine, but not methadone, and lowered brain 5-HT. The decrement in analgesic activity of morphine was reversed by pretreatment with 5-hydroxytryptophan. Lesions of the raphe magnus, a descending 5-HT system, antagonized the analgesic potency of both morphine and methadone. These experiments indicate a differential effect of 5-HT manipulation on opiate-induced analgesia, suggesting a different mechanism of analgesic action for morphine and methadone. |
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| Keywords: | Medial raphe Raphe magnus Morphine Methadone Analgesia |
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