| 线粒体自噬在眼科相关疾病中的研究进展 |
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| 引用本文： | 许君彧,张晓梅.线粒体自噬在眼科相关疾病中的研究进展[J].国际眼科杂志,2018,18(3):478-481. |
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| 作者姓名： | 许君彧 张晓梅 |
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| 作者单位： | 中国黑龙江省哈尔滨市,哈尔滨医科大学附属第一医院眼科医院,中国黑龙江省哈尔滨市,哈尔滨医科大学附属第一医院眼科医院 |
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| 摘 要： | 线粒体自噬是一种选择性自噬，是指细胞通过自噬的机制选择性地清除线粒体的过程。线粒体自噬在清除功能失调的线粒体、降低线粒体数量及维持细胞稳态中起着重要的作用。它的分子机制涉及PINK1/Parkin、BNIP3、NIX和FUNDC1等多种蛋白。线粒体发生功能障碍或损坏都可能造成严重的后果，甚至导致细胞死亡。研究发现线粒体自噬紊乱与多种眼科疾病的发生有关，如白内障、青光眼、年龄相关性黄斑变性(age-related macular degenration， AMD)、糖尿病视网膜病变(diabetic retinopathy， DR)等。本文就线粒体自噬的发生机制和它在眼科相关疾病中的研究进行综述。
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| 关 键 词： | 线粒体自噬机制 白内障 年龄相关性黄斑变性 糖尿病视网膜病变 视神经发育 |
| 收稿时间： | 2017/9/11 0:00:00 |
| 修稿时间： | 2018/1/29 0:00:00 |
Research progress of mitophagy in ophthalmic related diseases |
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| Jun-Yu Xu and Xiao-Mei Zhang.Research progress of mitophagy in ophthalmic related diseases[J].International Journal of Ophthalmology,2018,18(3):478-481. |
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| Authors: | Jun-Yu Xu and Xiao-Mei Zhang |
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| Institution: | Eye Hospital, the First Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang Province, China and Eye Hospital, the First Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang Province, China |
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| Abstract: | Mitophagy is a selective autophagy refers to the autophagy process by which cells selectively remove mitochondria. Mitophagy plays important roles in clearing up dysfunctional mitochondria, reducing mitochondrial numbers and maintaining cell homeostasis. Its molecular mechanisms involve several proteins such as PINK1/Parkin, BNIP3, NIX, and FUNDC1. Mitochondrial dysfunction or damage may cause serious consequences, and may even lead to cell death. Studies have shown that disfunction of mitophagy is related to many eye diseases, for instance, cataract, glaucoma, age-related macular degeneration, diabetic retinopathy, etc. This review deals with the mechanisms of mitophagy and its research on ocular diseases. |
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| Keywords: | mechanisms of mitophagy cataract age-related macular degeneration diabetic retinopathy optic nerve development |
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