金黄散对比硫酸镁治疗输液所致静脉炎的系统评价

[目的]系统评价金黄散与硫酸镁比较治疗输液所致静脉炎的临床疗效。[方法]计算机检索Pub Med、Cochrane Library、EMbase、维普数据库(VIP)、中国知网(CNKI)和中国生物医学文献服务系统(CBM)等数据库,查找应用金黄散与硫酸镁比较治疗输液所致静脉炎的临床随机对照研究(RCT)。由两名研究者按照纳入与排除标准独立进行文献筛选、资料提取和质量评价后,采用Rev Man 5.0.2软件进行Meta分析。[结果]最终纳入14个RCT,970例患者。Meta分析结果显示,与硫酸镁相比,应用金黄散外敷治疗可以提高输液所致静脉炎患者的总有效率[OR=9.87,95%CI(5.40,18.04),P0.000 01]和愈显率[OR=5.47,95%CI(3.88,7.71),P0.000 01]方面,两组差异有统计学意义。[结论]本系统评价结果显示,应用金黄散外敷治疗可以明显提高输液所致静脉炎患者的总有效率,增加愈显率。总体而言,金黄散治疗输液所致静脉炎的治愈率高,价格便宜,使用方便,无明显毒副作用,值得临床推广使用。

A systematic review on the effect of phlebitis caused by transfusion treated by Jinhuang powder and magnesium sulfate

[Objective] To evaluate the clinical efficacy of Jinhuang powder for phlebitis caused by transfusion.[Methods] Randomized controlled trials (RCTs) on Jinhuang powder for phlebitis caused by transfusion were searched in PubMed, Cochrane Library, EMbase, VIP, CNKI, CBM and other electronic databases. Studies were screened according to the inclusion and exclusion criterion, and data were extracted and assessed with two researchers. Meta-analyses were performed with RevMan 5.0.2 software.[Results] Among the 14 RCTs, 970 cases were included. Meta-analyses showed Jinhuang powder could increase the tota1 effective rate[OR=9.87,95%CI(5.40, 18.04),P<0.000 01] compared with the magnesium sulfate. There were significant differences between the two groups in the curing and excellence[OR=5.47,95%CI(3.88, 7.71),P<0.000 01].[Conclusion] The present results of systematic review showed that Jinhuang powder could increase the total effective rate compared with the magnesium sulfate for phlebitis caused by transfusion, and could increase the curing and excellence. Therefore, Jinhuang powder is high curative rate, lower price, simple application and no obvious side effect in treating phlebitis caused by transfusion. It is worthy of wide application.