CAPN4在结直肠癌中的表达及其临床意义

目的 研究CAPN4（calpain small subunit 1）在结直肠癌中的表达及其临床意义。方法 免疫组织化学法检测10对结直肠癌组织和相应的癌旁非瘤组织中CAPN4的表达，并检测74例结直肠癌组织中CAPN4的表达，结合临床随访资料探讨其表达与临床病理因素和预后的相关性。结果 结直肠癌组织中CAPN4的表达均高于相应的癌旁非瘤组织。CAPN4的表达强度与结直肠癌患者的Dukes分期（P=0.000），TNM分期（P=0.000），病理分级（P=0.021）和生存预后（P=0.040）显著相关，而与患者的年龄和性别无相关性。Kaplan-Meier分析显示，CAPN4高表达病例组生存时间明显少于CAPN4低表达病例组，经Log-rank检验，差异有统计学意义。结论 CAPN4在结直肠癌中表达上调，其表达差异与结直肠癌Dukes分期、TNM分期、病理分级和患者生存预后呈显著负相关，提示其可能与结直肠癌的发生、发展相关。

Expression and Clinical Significance of CAPN4 in Human Colorectal Cancer

Objective To investigate the expression and clinical significance of calpain small subunit 1 (CAPN4) in colorectal cancer(CRC).Methods The expression of CAPN4 was detected by immunohistochemistry in 10 cases of CRC tissues and the adjacent non-tumor tissues and 74 samples CRC tissues. Clinicopathological data was analyzed to reveal the correlation between CAPN4 expression and clinicopathological characteristics and prognosis of CRC patients.Results Immunohistochemistry analysis showed that CAPN4 expression in CRC tissues was higher than that in adjacent non-tumor tissues. CAPN4 expression was significantly correlated with Dukes'' stages (P=0.000), TNM stages (P=0.000), histopathological grading (P=0.021) and prognosis (P=0.04), whereas CAPN4 expression was not correlated with patient age and gender. Kaplan-Meier analysis demonstrated that high CAPN4 expression was correlated with a short survival time.Colocusion The increased expression of CAPN4 was significantly correlated with Dukes'' stages, TNM stages, histopathological grading and prognosis in CRC, indicating that it may play a role in the oncogenesis and development of CRC.