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Regulatory/modulatory effect of prune essence concentrate on intestinal function and blood lipids
Authors:Hui-Fang Chiu  Yun-Chien Huang  Yan-Ying Lu  Yi-Chun Han  You-Cheng Shen  Oksana Golovinskaia
Affiliation:1. Department of Chinese Medicine, Taichung Hospital, Ministry of Health and Well-being, Taichung, Taiwan, ROC;2. School of Nutrition, Chung Shan Medical University, Taichung City, Taiwan, ROC;3. Department of Neurology, Chung Shan Medical University, Taichung City, Taiwan, ROC;4. School of Health Diet and Industry Management, Chung Shan Medical University, Taichung City, Taiwan, ROC;5. ITMO University, Saint-Peterburg, Russia
Abstract:Context: Prunus domestica Linn (Rosaceae) has been considered a functional food, owing to its various pharmacological activities, including antioxidant, anti-inflammatory, antidiabetic and anticancer.

Objective: This placebo-controlled, randomized study was framed to check the beneficial activity of prune essence concentrates (PEC) in corroboration with intestinal function and lipid profile in mildly hypercholesterolemic subjects.

Materials and methods: Sixty healthy mild hypercholesterolemic subjects were randomly chosen and segregated into three groups as placebo (consume 50?mL of simulated prune drink), PEC I (consume 50?mL of PEC/day) and PEC II (consume 100?mL of PEC/day) for 4 weeks with 2 weeks of follow-up without PEC consumption.

Results: Intake of PEC (I and II) for 4 weeks substantially ameliorated (p?Bifidobacterium spp. (1.18- and 1.19-fold) and Lactobacillus spp. (1.07- and 1.16-fold), but markedly lowered (p?Clostridium perfringens (5.97 and 8.35%) and Escherichia coli (6.25 and 9.38%). Meanwhile, the total cholesterol (TC; 5.90 and 6.99%) levels and LDL-c (6.68 and 6.53%) were significantly reduced (p?p?Discussion and conclusion: Overall, the results suggest that the use of PEC may positively regulate the intestinal microflora and thereby effectively lower the TC levels and thus act as a hypocholesterolemic agent.
Keywords:Hypercholesterolemic  intestinal microflora  lipid profile  antioxidant capacity
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