Beneficial effects of tyrosol on altered glycoprotein components in streptozotocin-induced diabetic rats

Context: Olive oil is the major source of tyrosol which is a natural phenolic antioxidant. Olive oil constitutes a major component of the Mediterranean diet that is linked to a reduced incidence of chronic diseases.

Objective: This study evaluates the effects of tyrosol on altered glycoprotein components in streptozotocin-induced diabetic rats.

Materials and methods: Diabetes mellitus was induced in male Wistar rats by streptozotocin (40?mg/kg body weight). These rats were administered tyrosol (20?mg/kg body weight) and glibenclamide (600?μg/kg body weight) orally daily for 45?days. Plasma glucose, plasma insulin, glycoprotein components such as hexose, hexosamine, sialic acid and fucose in the plasma, liver and kidney, and histopathogy of tissues were analyzed.

Results: Diabetic rats revealed significant (p?p?p?in vitro study revealed the antioxidant effect of tyrosol.

Discussion and conclusions: Thus, tyrosol protects streptozotocin-induced diabetic rats from the altered glycoprotein components. Further, this study can be extrapolated to humans.