Hepatoprotective effect of Stachys pilifera ethanol extract in carbon tetrachloride-induce hepatotoxicity in rats |
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| Authors: | Esmaeel Panahi Kokhdan Kyomarth Ahmadi Heibatollah Sadeghi Fahemeh Dadgary Nazanin Danaei |
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| Institution: | 1. Department of Biology, Faculty of Science, University of Guilan, Rasht, Iran;2. Biochemistry Department, Faculty of Medicine, AJA University of Medical Sciences, Tehran, Iran;3. Medicinal Plants Research Center, Yasuj University of Medical Sciences, Yasuj, Iran;4. School of Nursing, AJA University of Medical Sciences, Tehran, Iran |
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| Abstract: | Context: Stachys pilifera Benth (Lamiaceae) has long been used to treat infectious diseases, respiratory and rheumatoid disorders in Iranian folk medicine. Antitumor and antioxidant activity of the plant have been reported.Objective: The study was designed to assess the hepatoprotective activity of ethanol extract of Stachys pilifera in carbon tetrachloride (CCl4)-induced hepatotoxicity in rats.Materials and methods: The rats were randomly divided into six equal groups (n?=?7). Group I was treated with normal saline; Group II received CCl4 (1?mL/kg. i.p., twice a week) for 60 consecutive days; Groups III, IV and V were given CCl4 plus Stachys pilifera (100, 200 and 400?mg/kg/d,p.o.); Group VI received the extract (400?mg/kg/d, p.o.). Histopathological analysis and measurement of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), malondialdehyde (MDA), total protein (TP) and albumin (ALB) were performed.Results: CCl4 caused a significant increase in the serum levels of AST, ALT, ALP and MDA as well as decreased ALB, and TP serum levels (p?4-elevated levels of ALT, AST, ALP and MDA (p?4 group (p4.Discussion: The results revealed that the Stachys pilifera extract could provide considerable protection against CCl4 hepatotoxicity in rats that may be related to its antioxidant properties. |
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| Keywords: | AST ALP hepatotoxicity MDA |
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