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Aortic diameter at age 65 in men with newly diagnosed type 2 diabetes
Authors:Soumia Taimour  Jan Holst  Anders H Rosengren  Leif Groop  Peter M Nilsson
Institution:1. Department of Vascular Diseases, Lund University, Sk?ne University Hospital, Malm?, Sweden;2. Department of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden;3. Department of Internal Medicine, Clinical Research Unit, Sk?ne University Hospital, Malm?, Sweden;4. Department of Internal Medicine, Clinical Research Unit, Sk?ne University Hospital, Malm?, Sweden
Abstract:Objectives. Type 2 diabetes mellitus has been linked to a decreased risk for abdominal aortic aneurysm (aortic diameter ≥30?mm, AAA) development in men. The aim of this study was to evaluate if such an effect is detectable already around the time of diabetes diagnosis. Design. We cross-sectionally compared aortic diameter at ultrasound screening for AAA in 691 men aged 65 years with incipient or newly diagnosed type 2 diabetes (group A) with 18,262 65-year old control men without diabetes (group B). Results. Aortic diameter did not differ between groups (18.817.4–20.8] vs. 19.017.5–28.7] mm; p?=?0.43). AAA prevalence was 2.5% in group A and 1.5% in group B (p?=?.010). In logistic regression taking group differences in body mass index (BMI), smoking, presence of atherosclerotic disease and hypertension into account, the difference in AAA prevalence was no longer significant (p?=?.15). Among men in group A, C-peptide (r?=?.093; p?=?.034), but not HbA1c (r?=?.060; p?=?.24) correlated with aortic diameter. Conclusion. Among 65 year old men aortic diameter and AAA prevalence do not differ between those with newly diagnosed type 2 diabetes and those without diabetes. Putative protective effects of type 2 diabetes mellitus against aortic dilatation and AAA development therefore probably occur later after diagnosis of diabetes.
Keywords:Abdominal aortic aneurysm  aortic diameter  type 2 diabetes  ultrasound  screening
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