| 尼索地平光解产物的制备及药理作用 |
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| 引用本文： | 赵敬琴,武引文,颜廷仁,聂辉,任雷鸣,李蕴山,傅绍萱. 尼索地平光解产物的制备及药理作用[J]. 河北医科大学学报, 1990, 0(1) |
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| 作者姓名： | 赵敬琴 武引文 颜廷仁 聂辉 任雷鸣 李蕴山 傅绍萱 |
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| 作者单位： | 石家庄医专，河北医学院有机化学教研室，河北医学院有机化学教研室，河北医学院有机化学教研室，河北医学院药理学教研室，河北医学院药理学教研室，河北医学院药理学教研室 |
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| 摘 要： | 本文报道了尼索地平光解产物的制备及其药理和毒性实验。结果表明:给家兔静脉注射光解产物,有微弱而短暂的降压作用,给小鼠灌胃无任何毒性,而腹腔注射则有一些毒性,故尼索地平注射剂中应严格控制光解产物的含量。
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| 关 键 词： | 尼索地平 光解产物 降压作用 毒性 |
PREPARATION OF NISOLDIPINE PHOTOLYTIC PRODUCT AND ITS PHARMACOLOGICAL ACTION |
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| Zhao jingqin Wu Yinwen Yan Tingren Nie Hui Ren Leiming Li Yunshan Fu Shaoxuan. PREPARATION OF NISOLDIPINE PHOTOLYTIC PRODUCT AND ITS PHARMACOLOGICAL ACTION[J]. Journal of Hebei Medical University, 1990, 0(1) |
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| Authors: | Zhao jingqin Wu Yinwen Yan Tingren Nie Hui Ren Leiming Li Yunshan Fu Shaoxuan |
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| Affiliation: | Department of Organic Chemistry Dcpartment of Pharmacology |
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| Abstract: | The preparing processes of the nisoldipine photolytic product and its generaIpharmacological actions as well as acute toxicities were reported. In rabbit,iv administration of the photolytic product induced slight and transient depressor effect. In mouse, ig of this product exhibited no toxicities, but there were some toxicities after ip administration. Therefore, the content ofnisoldipine photolytic product should be strictly controlled in the injections. |
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| Keywords: | nisoldipine photolytic product depressor effect toxicity |
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