南宁市正常人群风疹免疫水平检测及风疹活疫苗免疫效果观察

本文对1,043份血清标本的分析表明风疹血抑抗体阴性率为29.1%,且16~30岁人群中风疹血抑抗体滴度<1:32的比例较高。193名儿童接种RA27/3株风疹减毒活疫苗后,血清抗体阳转率为95.1%;免后一年的疫苗保护率为98.8%。免疫儿童中发生风疹血清再感染的占5.6%,且与免疫后抗体滴度偏低有关。

Investigation on the level of Antibodies against Rubella in population of Normal Persons in Nanning City and A survey of the Immunizing Efficacy of Rubella Live Vaccine

Sera from 1,043 normal persons in Nanning of Guangxi Autonomous region were tested for antibodies against rubella virus with haemagglutination inhibition test. The negative rate of HI antibodies were 29.1%.In the age group of 16~30 years there was large proportion with low titre of HI antibody to rubella.193 antibody-negative children aged 1-5 years were immunized with RA27/3 strain attenuated rubella live-vaccone. The seroconversion rate of HI antibody one month after vaccintion was 95.1%, One year after vaccination the Protection rate was 98.8%. The reinfection rate of rubella in immunized childern was 0.5% (Control:40%). The rubella cases mainly occured in those (occupying 5.6% among vaccinated) With low titre of HI antibody after vaccination.