中西医结合治疗与单纯西医治疗肺癌疗效的Meta分析

目的：系统评价中西医结合与单纯西医药治疗肺癌（lung cancer）的疗效和不良反应。方法：计算机检索中国生物医学文献数据库、中国期刊网、万方数据库、维普数据库,并配合手工检索所有文献全文,由两位评价者分别对资料进行质量评价,用Revman 5.1进行meta分析,主要对实体瘤近期疗效、生存质量、不良反应进行分析。结果：共纳入16个随机对照试验,目前资料的meta分析结果显示：临床治疗有效率：异质性检验P=0.78,表明研究数据具有同质性,故采用固定效应模式,合并效应量的OR=2.06,95%的可信区间为1.61～2.63,P〈0.00001,差异有统计学意义,提示中西医结合治疗组优于单纯化疗组;患者生存质量改善：OR=3.07,95%的可信区间为2.18～4.33,P〈0.00001,差异有统计学意义,提示中西医结合治疗组优于单纯化疗组;不良反应发生：1白细胞减少/骨髓抑制OR=0.29,95%的可信区间为0.21～0.40,P〈0.00001,差异有统计学意义,提示中西医结合治疗组优于单纯化疗组;2胃肠道反应（恶心、呕吐）OR=0.25,95%的可信区间为0.15～0.42,P〈0.00001,差异有统计学意义,提示中西医结合治疗组优于单纯化疗组。结论：中西医结合治疗肺癌的疗效优于单纯西药。

Meta-analysis of Integration of Traditional and Western Medicine Treatment Versus Western Treatment in Patients with Lung Cancer

Objective： To compare the effect of integration of traditional Chinese and Western medicine with western medicine therapy for lung cancer. Methods： Relevantliteratures were reviewed via database and assessed via randomized controlled trial（RCT） scale. All reviewed literatures were assessed via Jadad quality scale. Data statistical analysis was performed by RevMan5. 1 software. Results： Clinical efficient：since test for heterogeneity： P = 0. 78,it indicated the data had homogeneity,so we used the fixed effect model. OR = 2. 06,95% CI 1. 61 ～ 263,P〈0. 01（P〈0. 00001）. It meant that integration of traditional Chinese and Western medicine treatment for lung cancer in improving clinical symptom had obvious advantages compared with Western medicine. For evaluation of quality of life,OR = 3. 07,95% CI 2. 18 ～ 4. 33,P〈0. 01（P〈0. 00001）. It meant that integration of traditional Chinese and Western Medicine treatment for colorectal cancer in improving quality of life had obvious advantages compared with Western medicine. For the main toxicity： 1occurrence of hematological toxicity：OR = 0. 29,95% CI 0. 21 ～ 0. 40,P〈0. 01（P〈0. 00001）;2occurrence of neurotoxicity：OR = 0. 25,95% CI 0. 15 ～ 0. 42,P〈0. 01（P〈0. 00001）. They meant that integration of traditional Chinese and Western medicine treatment for colorectal cancer in reducing toxicity had obvious advantages compared with Western medicine. Conclusion：Integration treatment for lung cancer shows good curative effect,and there are obvious advantages compared with Western medicine.