311例同一个体食管/贲门(胃)双源癌患者临床病理特征及生存影响因素分析 |
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引用本文: | 彭秀青,;黄佳,;张鹏飞,;刘静,;袁果,;李贝,;王立东,;冯笑山. 311例同一个体食管/贲门(胃)双源癌患者临床病理特征及生存影响因素分析[J]. 肿瘤基础与临床, 2014, 0(3): 248-252 |
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作者姓名: | 彭秀青, 黄佳, 张鹏飞, 刘静, 袁果, 李贝, 王立东, 冯笑山 |
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作者单位: | [1]河南科技大学第一附属医院肿瘤科,河南洛阳471003; [2]郑州大学第一附属医院河南省食管癌重点开放实验室,河南郑州450052 |
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基金项目: | 国家科技部863重大项目(编号:2012AA02A201) |
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摘 要: | 目的通过分析食管鳞癌/贲门(胃)双源癌(CC)患者临床病理特征,探讨影响双源癌患者生存期的关键因素。方法收集来自食管癌高发区的311例双源癌患者资料,从治疗医院获得病理资料,进行生存随访,并分析双源癌患者临床病理特征及影响生存期的因素。结果 1)漏诊率34.7%;男女性别比为4.9∶1;不同性别患者肿瘤类型均以食管鳞癌/贲门腺癌为主;2)食管癌、贲门癌TNM分期均以Ⅱ期为主,Ⅳ期最少,但贲门癌Ⅲ~Ⅳ期明显多于食管癌(P〈0.05);2种肿瘤分化程度、T分期、N分期及临床分期一致性差(Kappa值均〈0.2);3)T分期及N分期是影响双源癌患者预后的独立因素(P〈0.05)。结论双源癌患者漏诊率高,病理一致性差,预后影响因素复杂。
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关 键 词: | 双源癌 临床病理特征 漏诊 生存期 |
Analysis of influencing Factors of Survival and Clinicopathologic Features for 311 Patients with Concurrent Emphageal and Gastric Cardht Carcinoma |
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Affiliation: | Peng Xiuqing Huang jia ,Zhang Pengfei , Liu Jing, Yuan Guo, Li Bei, Wang Lidong, Feng Xiaoshan ( 1.Department of Oncology, the First Affiliated Hospital, Henan University of Science and Technology, Luoyang 471003, China; 2. Henan Key Laboratory for Esophageal Cancer Research, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052,China) |
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Abstract: | Objective To investigate the influencing factors of survival for patients with concurrent esophageal and gastric (eardia) carcinoma by the analysis of chinicopatholgic features. Methods The basic data of 311 pa- tients with concurrent esophagus and gastric(cardia)cancinoma were collected, all the patients were from the high incidence area of esophageal carcinoma, The ctinlcaopathological data were got from hospital, and then a follow-up for survival was taken,The clinicaopathological features of the patients and the factors affecting survival were ana- lyzed. Results 1 ) The rate of missed diagnosis was 34, 7% ; overall sender ratio for male to female was 4.9 : 1 ; the histological types of tumor was based on esophageal squamous cell carcinoma,/gaatric eardia adenoeareinoma; 2 ) the TNM stage of esophageal squamous cell carcinoma and gastric cardia adenoearcinoma were all based on stage Ⅱ ,the stage Ⅳ was the least,but the stage Ill-iV of gastric gardia adennocareitlnoma was sttglaificantly more than e- sophageal squamous cell carcinoma (P 〈 0.05 ) ; the consistency of tlifferentiation degree, T stage, N stage and clini- cal stage of esophageal squamous cell carcinoma and gastric cardia adenocarcinoma were poor( the values of Kappa were less than 0.2) ; 3 ) T and N stage werethe indpendent prognostic factors for the patients with concurrent e- sophageal and gastric(cardia) carcinoma (P 〈0.05 ). Conclusion The rate of missed diagnosis of patients with concurrent esophageal and gastric (cardia) carcinoma is very high; the consistency of two tumors is poor; the factors of effected survivM are complicated. |
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Keywords: | concurrent carcinoma clinicopathologic features missed diagnosis survival time |
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