| 液化石油气中毒大鼠的行为学与病理研究 |
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| 引用本文： | 白润涛,李竞,葛朝莉,韩漫夫.液化石油气中毒大鼠的行为学与病理研究[J].中国实用神经疾病杂志,2009,12(2). |
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| 作者姓名： | 白润涛 李竞 葛朝莉 韩漫夫 |
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| 作者单位： | 广东深圳市第二人民医院神经内科,深圳,518035 |
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| 摘 要： | 目的 观察大鼠急性液化石油气中毒后行为学和病理变化.方法 采用大鼠液化石油气中毒模型、水迷宫实验观察大鼠逃避潜伏期、在无平台水迷宫中第1次穿越平台所在位置的时间和在平台所在象限游泳距离,实验大鼠分别于中毒后2、3、5d处死取脑,HE染色观察神经细胞形态.结果 水迷宫实验中中毒组动物逃避潜伏期明显延长,在无平台水迷宫中第1次穿越平台所在位置的时间明显延长,在平台所在象限游泳距离缩短.光镜下见中毒组大鼠神经元细胞核浓缩、结构不清.结论 液化石油气中毒导致神经元细胞坏死,从而损害大鼠的学习记忆认知功能.
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| 关 键 词： | 液化石油气中毒 Morris水迷宫 神经细胞 大鼠 |
Behavioral and pathological observation of liquid petroleum gas poisoning in rats |
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| Bai Runtao,Li Jing,Ge Zhaoli,et al..Behavioral and pathological observation of liquid petroleum gas poisoning in rats[J].Chinese Journal of Practical Neruous Diseases,2009,12(2). |
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| Authors: | Bai Runtao Li Jing Ge Zhaoli |
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| Institution: | Bai Runtao,Li Jing,Ge Zhaoli,et al.Department of Neurology,Shenzhen Second People's Hospital,Shenzhen 518035,China |
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| Abstract: | Objective To observe the behavioral and pathological changes of liquid petroleum gas poisoning rat.Methods Liquid petroleum gas poisoning model of rats were used.The escape latency and the first time passing hidden platform and the distance of swimming in the quadrant of hidden platform were recorded through Morris water maze task.The rats were killed at 2,3,5d after poisoning.The morphological changes of neurocyte were observed by HE staining.Results The escape latency increased significantly in poisoning ... |
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| Keywords: | Liquid petroleum gas poisoning Morris water maze Neurocyte Rat |
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