Piceatannol, a natural stilbene from grapes, induces G1 cell cycle arrest in androgen-insensitive DU145 human prostate cancer cells via the inhibition of CDK activity |
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| Authors: | Yeo Myeong Lee Do Young Lim Han Jin Cho Mi Ra Seon Jin-Kyung Kim Boo-Yong Lee Jung Han Yoon Park |
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| Affiliation: | aDepartment of Food Science and Nutrition, Hallym University, Chuncheon 200-702, Republic of Korea;bCenter for Efficacy Assessment and Development of Functional Foods and Drugs, Hallym University, Chuncheon 200-702, Republic of Korea;cGraduate School of Complementary and Alternative Medicine, CHA University, Seongnam-si 463-836, Republic of Korea |
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| Abstract: | We have examined whether and by what mechanism piceatannol inhibits cell cycle progression in DU145 cells. The treatment of cells with piceatannol for 24 h resulted in an increase in the percentage of cells in G1 phase and dose-dependent decreases in [3H]thymidine incorporation, as well as in protein levels of cyclin A, cyclin D1, and cyclin-dependent kinase (CDK)2 and CDK4. Piceatannol exerted no effect on the levels of p21WAF1/CIP1 or p27KIP1. Piceatannol reduced CDK4 and CDK2 activity. These results indicate that delaying G1 cell cycle progression contributes to the piceatannol-mediated inhibition of DU145 cell growth, which may be mediated via the inhibition of CDK activity. |
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| Keywords: | Piceatannol Cell cycle progression Cyclin-dependent kinase |
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