| 脊柱膜与生物蛋白胶联合应用预防硬膜外粘连的实验研究 |
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| 引用本文： | 徐江波,袁宏,王浩,赵喜滨. 脊柱膜与生物蛋白胶联合应用预防硬膜外粘连的实验研究[J]. 脊柱外科杂志, 2008, 6(5): 293-296 |
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| 作者姓名： | 徐江波 袁宏 王浩 赵喜滨 |
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| 作者单位： | 新疆维吾尔自治区人民医院骨一科,新疆维吾尔自治区,830001;新疆维吾尔自治区人民医院骨一科,新疆维吾尔自治区,830001;新疆维吾尔自治区人民医院骨一科,新疆维吾尔自治区,830001;新疆维吾尔自治区人民医院骨一科,新疆维吾尔自治区,830001 |
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| 摘 要： | 目的观察椎板切除术后联合使用脊柱膜与生物蛋白胶预防硬膜外粘连的效果,探讨从三维上预防粘连的最佳方案。方法本课题采用动物实验,运用拉丁方实验设计,分别做无植入（A组）,植入生物蛋白胶（B组）,脊柱膜（C组）,脊柱膜和生物蛋白胶（D）于兔的4个节段,术后4周对椎板切除部位进行大体观察、组织学观察及MR I检查,比较各组瘢痕形成和粘连情况。结果①A组可见大量瘢痕组织增生,以硬膜囊后方明显,粘连严重。②B组防粘连的效果差。③C组的防粘连的效果优于A组和B组,但差于D组。④D组,不但能够防止后方肌肉及疤痕组织的长入,而且可防止前方、周围硬膜及神经根的粘连。结论联合使用硬体材料脊柱膜和流体材料生物蛋白胶是防止椎板切除术后硬膜粘连的最佳方案。
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| 关 键 词： | 腰椎 椎板切除术 硬膜 瘢痕 纤维蛋白组织黏着剂 聚四氟乙烯 |
| 收稿时间： | 2007-06-04 |
Prevention of epidural adhesion after laminectomy by expanded polytetrafluoroethylene combined with fibrin sealant |
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| XU Jiangbo,YUAN Hong,WANG Hao and ZHAO Xibin. Prevention of epidural adhesion after laminectomy by expanded polytetrafluoroethylene combined with fibrin sealant[J]. Journal of Spinal Surgery, 2008, 6(5): 293-296 |
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| Authors: | XU Jiangbo YUAN Hong WANG Hao ZHAO Xibin |
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| Affiliation: | XU Jiangbo,YUAN Hong,WANG Hao,ZHAO Xibin.Department of Orthopaedics,People's Hospital of Xinjiang Uygur Autonomous Region,Urumqi 830000,China |
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| Abstract: | Objective To observe the effect of expanded polytetrafluoroethylene(ePTFE) combined with fibrin sealant(FS) in prevention of fibrous scar formation in the epidural space after laminectomy.Methods According to the scheme of Latin square design,wide laminectomv was performed at 4 sections of spine in healthy adult New Zealand rabbit.And the exposed duras were covered with nothing(group A),ePTFE(group B),FS(group C) and ePTFE+FS(group D) respectively.Gross,histological and MRI observation of the vertebral lami... |
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| Keywords: | Lumbar vertebrae Laminectomy Dura mater Cicatrix Fibrin tissue adhesive Polytetrafluoroethylene |
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