| 新诊断2型糖尿病患者血清n-3多不饱和脂肪酸与超敏C反应蛋白相关性研究 |
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| 引用本文： | 楼大钧,朱麒钱,斯徐伟,官莉莉,尤巧英,张爱珍,李铎.新诊断2型糖尿病患者血清n-3多不饱和脂肪酸与超敏C反应蛋白相关性研究[J].苏州大学学报(自然科学版),2010,30(2):355-357. |
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| 作者姓名： | 楼大钧 朱麒钱 斯徐伟 官莉莉 尤巧英 张爱珍 李铎 |
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| 作者单位： | 楼大钧,朱麒钱,斯徐伟,官莉莉,尤巧英,LOU Da-jun,ZHU Qi-qian,SI Xu-wei,GUAN Li-li,YOU Qiao-ying(绍兴市人民医院内分泌代谢病科,浙江绍兴,312000);张爱珍,ZHANG Ai-zhen(浙江大学城市学院医学与生命科学学院,浙江杭州,310020);李铎,LI Duo(浙江大学食品科学与营养系,浙江杭州,310029) |
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| 基金项目： | 浙江省医药卫生科学研究基金重点项目，绍兴市科技局霞点资助项目 |
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| 摘 要： | 目的研究新诊断2型糖尿病患者血清n-3多不饱和脂肪酸与超敏C反应蛋白的关系。方法对60例新诊断2型糖尿病患者（T2DM组）和55例健康对照者（NC组）应用高效气相色谱法测定血清磷脂脂肪酸谱,颗粒增强免疫沉淀法测定血清超敏C反应蛋白（hs-CRP）水平。结果 T2DM组的n-3多不饱和脂肪酸（n-3PUFA）总量为（6.08±1.66）%,较NC组的（9.54±1.54%）显著降低（P〈0.01）;T2DM组的血清hs-CRP为（7.26±1.34）mg/L,明显高于NC组的（0.83±0.42）mg/L（P〈0.01）;相关性分析显示,hs-CRP浓度与n-3PUFA总量负相关（P〈0.05）。结论新诊断2型糖尿病患者血清n-3PUFA含量低于健康者,血清hs-CRP与n-3PUFA总量成负相关关系。
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| 关 键 词： | 2型糖尿病 n-3多不饱和脂肪酸 超敏C反应蛋白 |
Serum n-3 Polyunsaturated Fatty Acid and High-sensitivity C Reactive Protein in Patients with Newly Diagnosed Type 2 Diabetes Mellitus |
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| LOU Da-jun,ZHU Qi-qian,SI Xu-wei,GUAN Li-li,YOU Qiao-ying,ZHANG Ai-zhen,LI Duo.Serum n-3 Polyunsaturated Fatty Acid and High-sensitivity C Reactive Protein in Patients with Newly Diagnosed Type 2 Diabetes Mellitus[J].Suzhou University Journal of Medical Science,2010,30(2):355-357. |
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| Authors: | LOU Da-jun ZHU Qi-qian SI Xu-wei GUAN Li-li YOU Qiao-ying ZHANG Ai-zhen LI Duo |
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| Institution: | 1.Dept of Endocrinology,Shaoxing People’s Hospital,Zhejiang Shaoxing 312000,China;2.School of Medical and Life Sciences,Zhejiang University City College,Zhejiang Hangzhou 310020,China;3.Dept of Food Science and Nutrition,Zhejiang University,Zhejiang Hangzhou 310029,China) |
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| Abstract: | Objective To investigate the serum n-3 polyunsaturated fatty acid and its relationship with high-sensitivity C reactive protein in patients with newly diagnosed type 2 diabetes mellitus.Methods Serum phospholipid fatty acid profile was analyzed with capillary gas chromatography.Immunolurbidimelric assay was used to measure the serum high-sensitivity C reactive protein （hs-CRP）.Results The levels of n-3 Polyunsaturated fatty acid（n-3PUFA） was lower in newly diagnosed type 2 diabetes mellitus group（T2DM）than those in NC group（6.08%±1.66% vs 9.54%±51.54%,P0.01）.The serum hs-CRP cocentration was significantly higher in T2DM group than that in NC group（7.26±1.34mg/L vs 0.83±0.42mg/L,P0.01）.Hs-CRP cocentration was negatively correlated with n-3PUFA（P0.05）.Conclusion Serum n-3 PUFA is lower in newly diagnosed T2DM patients than that in healthy people.Serum hs-CRP cocentration was negatively correlated with n-3PUFA. |
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| Keywords: | type 2 diabetes mellitus n-3 polyunsaturated fatty acid high-sensitivity C reactive protein |
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