Pituitary Adenomas that Show a Faint GH-Immunoreactivity but Lack Fibrous Body: Pit-1 Adenoma with Endocrinologically Low Activity |
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Authors: | Akiko Yoneda Toshiaki Sano Shozo Yamada Abdulkader Obari Zhi Rong Qian Elaine Lu Wang Naoko Inosita Eiji Kudo |
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Institution: | (1) Department of Human Pathology, Institute of Health Bioscience, University of Tokushima Graduate School, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan;(2) Department of Hypothalamic and Pituitary Surgery, Toranomon Hospital, Tokyo, Japan;(3) Department of Pathology, Toranomon Hospital, Tokyo, Japan; |
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Abstract: | Growth hormone (GH)-producing pituitary adenomas have been classified into densely and sparsely granulated adenomas. The latter
are chromophobic with weak GH-positivity and characteristically possess fibrous body (FB), aggregation of cytokeratin filaments.
We report eight cases of unusual chromophobic adenomas. GH-immunoreactivity was detected in most adenoma cells in five cases
and scattered in three cases. However, it appeared much weaker than that seen in ordinary GH-producing adenomas because of
spotty immunoreactivity. Although intracytoplasmic organelles were well-developed, secretory granules were small and sparse.
FB was not identified in any cases. Thyroid-stimulating hormone was positive in four cases. Pit-1 protein was positive in
all eight cases. A weak labeling with GH probe was detected in two of two cases examined by in situ hybridization. Acromegalic
features were evident in four cases, while mild or absent in four cases. GH levels were below 5 μg/l in four cases and 5–10 μg/l
in the remaining cases. Macroadenomas and invasive adenomas were seen in seven and six cases, respectively. |
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