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| 工业提取重楼薯蓣皂苷元的工艺研究 | |
| 引用本文： | 石森,李惠芬,李新元.工业提取重楼薯蓣皂苷元的工艺研究[J].天津药学,2010,22(5):74-76. |
| 作者姓名： | 石森 李惠芬 李新元 |
| 作者单位： | 1. 天津市安定医院,天津,300222 2. 天津医科大学药学院,中药分析国家重点实验室,天津,300070 3. 天津医科大学医学院,天津,300070 |
| 基金项目： | 天津市科委发展计划重点项目 |
| 摘 要： | 目的：优选适合药厂大批量提取重楼薯蓣皂苷元的工艺。方法：采用正交试验法,考查料液比、乙醇浓度、提取时间和提取次数对提取率的影响。以提取物酸水解所得薯蓣皂苷元的含量为指标筛选上述条件。结果：溶剂采用70%的乙醇、溶剂用量10倍量的原料体积、提取时间4h、提取次数3次为最佳工艺条件。结论：所筛工艺条件提高了重楼薯蓣皂苷元的收率,适用药厂大批量生产。 |
| 关 键 词： | 重楼 薯蓣皂苷元 正交试验 |
Technical study for industrial extraction of total saponin from Rhizoma Paridis |
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| Shi Sen,Li Huifen,Li Xinyuan.Technical study for industrial extraction of total saponin from Rhizoma Paridis[J].Tianjin Pharmacy,2010,22(5):74-76. | |
| Authors: | Shi Sen Li Huifen Li Xinyuan |
| Institution: | 1.Tianjin Anding Hospital,Tianjin 300222;2.College of Pharmacy,Tianjin Medical University,Laboratory of Chinese Materia Medica of China,Tianjin 300070;3.College of medical,Tianjin Medical University,Tianjin 300070) |
| Abstract: | Objective：To optimize the process for the mass-extraction of total saponin from Rhizoma Paridis which is fit for drug factory.Methods：Conditions such as feed-liquor ratio,concentration of ethanol,hours and times of extraction were studied by orthogonal design guided by the yield of yamogenin that is from acid hydrolysis product of extractive.Results：The optimal extraction process was found to be a single reflux with 10 times of 70%alcohol for 4 h 3 times.Conclusion：the extraction process from this test improved the rate of extraction and meet the requirement of mass-extraction in drug factory. |
| Keywords: | Rhizoma Paridis yamogenin orthogonal design |
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