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Acute Pulmonary Graft-Versus-Host Disease in a Patient with Adult T-cell Leukemia-Lymphoma Diagnosed by a Cryobiopsy |
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| Authors: | Hiroshi Kobe Machiko Arita Takeshi Maeda Osamu Nagata Takashi Niwa Fumiaki Tokioka Tadashi Ishida |
| Affiliation: | 1.Department of Respiratory Medicine, Ohara Healthcare Foundation, Kurashiki Central Hospital, Japan;2.Department of Hematology/Oncology, Ohara Healthcare Foundation, Kurashiki Central Hospital, Japan;3.Department of Respiratory Medicine, Kanagawa Cardiovascular and Respiratory Center, Japan |
| Abstract: | A 51-year-old woman with adult T-cell leukemia-lymphoma was hospitalized in order to undergo allogeneic hematopoietic stem-cell transplantation. On day 29 after transplantation, she began to experience hypoxia upon exertion. Chest computed tomography revealed centrilobular granular shadows, and pulmonary function tests revealed a remarkable obstructive ventilatory impairment compared to before transplantation. A histopathological analysis following a transbronchial lung cryobiopsy revealed acute graft-versus-host disease (GVHD). We herein report a rare case of histopathologically diagnosed acute pulmonary GVHD with spontaneous remission. |
| Keywords: | adult T-cell leukemia-lymphoma transbronchial lung cryobiopsy acute graft-versus-host disease spontaneous remission |