早产儿脑室周围白质软化与脐血一氧化氮的关系

目的探讨早产儿脑室周围白质软化(PVL)的高危因素、发病机制及其早期诊断方法。方法采集PVL早产儿宫内缺氧缺血病史;采用ELISA检测PVL早产儿脐血TORCH-IgM抗体;应用硝酸还原酶法检测脐血一氧化氮(NO)水平。结果PVL组52例早产儿中39例有宫内缺氧缺血病史且脐血TORCH-IgM抗体阳性率明显高于对照组(P<0.05);PVL组脐血NO水平明显高于对照组(P<0.05)。结论宫内缺氧缺血和感染是早产儿PVL的高危因素。过量NO可能在PVL发生机制中起重要作用;脐血NO水平检测对早产儿PVL有早期诊断价值。

Relationship between Periventricular Leukomalacia and Nitric Oxide in Cord Blood in Premature Infants

Objective To explore the high risk factors, pathogenesis and methods of early diagnosis of periventricular leukomalacia(PVL) in premature infants.Methods The history of intrauterine hypoxia-ischemia was investigated in premature infants;TORCH-IgM antibodies in cord blood of premature infants were measured by ELISA; Nitric oxide (NO) levels in their cord blood were determined by nitric acid reducing enzyme means. Results Thirty-nine of 52 premature infants in PVL group had a history of intrauterine hypoxia-ischemia; TORCH-IgM antibody positive rate in cord blood of premature infants in PVL group was significantly higher than that in control group(P< 0.05 );NO level in their cord blood was significantly higher than that in control group (P<0.05).Conclusions Intrauterine hypoxia ischemia and infection are two high risk factors of PVL in premature infants.Excessive NO maybe play a key role in development of PVL in premature infants.Determination of NO level in cord blood is valuable to early diagnosis of PVL in premature infants.