高脂血症对年龄相关性核性白内障患者晶状体密度影响分析

Objective To investigate the lens density of age-related nuclear cataract patients affected by hyperlipidemia. Methods A total of 136 cases (189 eyes) of age-related nuclear cataract patients were collected during the treatment from January 2007 to December 2008 in the Department of Ophthalmology, the Fourth People's Hospital of Shenyang, Liaoning. There were 39 male cases and 51 female cases, with the range of ages as 51-91, and averaged 71.3±8.6 years old. At the same time, 90 (180 eyes) cases of age-matched healthy persons over the same period were randomly selected as the control, with the range of ages as 54-83,and averaged 68.9±7.4 years old. For each subject, serum total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDLC), were determined after venous blood samples were collected. Meanwhile, eye examinations were performed to determine the lens density of LOCS Ⅲ grading and LogMAR visual acuity.Results The serum TC, TG and LDLC values of age-related nuclear cataract patients were 6.958 ± 1.87 mmol / L, 1.97 ± 0.71 mmol/ L and 4.17±1.83 mmol / L, respectively, which were significantly higher than that of the control group (4.26±0.78 mmol/ L, 1.29±0.48 mmol/ L and 2.85 ± 0.67 mmol/ L) respectively. The difference between two groups was significant (P ＜0.05) or very significant (P ＜0.01). The lens density, LOCS Ⅲ grading score and LogMAR visual acuity were significantly higher than that of the control group.There were significantly statistical differences between data of two groups (P ＜0.01). There were significant positive correlation between Serum TC, TG, LDLC and lens density among age-related nuclear cataract patients, the correlation 0.569, respectively (P ＜0.05 or P ＜0.01). Conclusions Hyperlipemia can increase lens density of age-related nuclear cataract patients, and is a risk factor of age-related cataract.

Study on the lens density of age-related nuclear cataract patients affected by hyperlipidemia